2. GPCR/G Protein
  3. GHSR
  4. Macimorelin

Macimorelin  (Synonyms: EP-1572; AEZS-130)

目录号: HY-14820
产品使用指南

摩尔计算器

Macimorelin (EP-1572)，一种 GH 促分泌素，是一种具有口服活性的 GHSR 激动剂。Macimorelin 可刺激 GH的释放。Macimorelin 可用于成人生长激素缺乏症 (AGHD) 和癌症厌食-恶病质综合征 (CACS) 的研究。

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Macimorelin Chemical Structure

Macimorelin Chemical Structure

CAS No. : 381231-18-1

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Macimorelin 的其他形式现货产品:

Customer Review

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Macimorelin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Macimorelin (EP-1572), a GH secretagogue, is an orally active GHSR agonist. Macimorelin stimulates GH release. Macimorelin can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

IC50 & Target

GHSR[1]
体内研究
(In Vivo)

Macimorelin (5 mg/kg, i.p. twice daily for 2 weeks) decreases the number and duration of seizures in IHKA mouse model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks.
Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.
Clinical Trial
分子量

474.55

Formula

C26H30N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Macimorelin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macimorelin381231-18-1EP-1572 AEZS-130EP1572EP 1572AEZS130AEZS 130AEZS-130GHSRGrowth hormone secretagogue receptorGhrelin receptorIHKAGHgrowth hormoneAGHDCACSInhibitorinhibitorinhibit

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