2. Epigenetics TGF-beta/Smad
  3. PKC
  4. MANS peptide

MANS peptide 是 MARCKS 的抑制剂，与细胞膜上与 MARCKS 竞争性结合，从而抑制粘蛋白分泌和肿瘤转移。

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Custom Peptide Synthesis

MANS peptide Chemical Structure

MANS peptide Chemical Structure

CAS No. : 479482-23-0

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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MANS peptide 的其他形式现货产品:

Customer Review

Other Forms of MANS peptide:

MANS peptide 相关抗体

Top Publications Citing Use of Products

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis[1].

体外研究
(In Vitro)

MANS peptide (0-100 μM，12-24 h) 抑制肺癌细胞 CL1-0/F3、CL1-5、PC9 和 A549 的迁移和侵袭，而不对正常细胞造成毒性[1]。
MANS peptide (0-100 μM，16 h) 抑制 MARCKS，PI3K 和 AKT 磷酸化，导致 Slug 信号下游和 E-钙粘蛋白表达水平的变化，防止细胞间粘附丧失，改变癌细胞的上皮-间质间转化 (EMT) 特征，从而减少肿瘤转移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MANS peptide 相关抗体:

Cell Viability Assay[1]

Cell Line: CL1-0/F3, CL1-5 and PC9
Concentration: 0-100 μM
Incubation Time: 12-24 h
Result: Inhibited migration.

Western Blot Analysis[1]

Cell Line: CL1-0/F3, CL1-5, PC9 and NHBE
Concentration: 0-100 μM
Incubation Time: 16 h
Result: Upregulated levels of E-cadherin, downregulated levels of Slug.
Suppressed MARCKS phosphorylation and AKT/Slug pathway.
体内研究
(In Vivo)

MANS peptide (50 nmol/injection，腹腔注射，每 3 天一次，共 6 次) 可抑制 PC9 异种移植 NOD/SCID 小鼠模型中的肿瘤转移，但不影响肿瘤发生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice model[1]
Dosage: 50 nmol/injection
Administration: Ip, every 3 days for 6 times
Result: Suppressed micrometastatic lesions.
分子量

2498.83

Formula

C111H184N30O35
CAS 号
Unlabeled CAS

Sequence

{Myristic acid-Gly}-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Ala-Lys-Gly-Glu-Ala-Ala-Ala-Glu-Arg-Pro-Gly-Glu-Ala-Ala-Val-Ala
Sequence Shortening

{Myristic acid-Gly}-AQFSKTAAKGEAAAERPGEAAVA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MANS peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MANS peptide479482-23-0PKCProtein kinase CCL1-0/F3CL1-5PC9A549NOD/SCID miceInhibitorinhibitorinhibit

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HY-P10218
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