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  3. Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

  • Food Chem Toxicol. 2018 Nov:121:24-36. doi: 10.1016/j.fct.2018.08.024.
Asad Ullah 1,  Madeeha Pirzada 2,  Sarwat Jahan 3,  Hizb Ullah 4,  Naheed Turi 5,  Waheed Ullah 6,  Mariyam Fatima Siddiqui 7,  Muhammad Zakria 8,  Kinza Zafar Lodhi 9,  Muhammad Munir Khan 10
Affiliations

Affiliations

  • 1 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: asadaryaan@gmail.com.
  • 2 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: madeehapirzada@gmail.com.
  • 3 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: drsarwatjahan@gmail.com.
  • 4 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: hizbullahwazir@gmail.com.
  • 5 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: Nancymirza90@gmail.com.
  • 6 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: waheedum@gmail.com.
  • 7 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: mariyamsiddiqui33@gmail.com.
  • 8 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: zakriakhan.qau@gmail.com.
  • 9 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: areehalodhi@gmail.com.
  • 10 Reproductive Physiology Lab, Department of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address: trendycsp@gmail.com.
PMID: 30120946 DOI: 10.1016/j.fct.2018.08.024
Abstract

Bisphenol A an estrogen-mimic endocrine disrupting chemical, used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Due to its toxicity, industries have started to replace it with Other bisphenols. In this study, the toxicity of BPA analogues (BPB, BPF and BPS) was evaluated in a chronic study. We investigated whether the chronic exposure to low bisphenols doses affects spermatogenesis with outcomes on oxidative stress and male reproductive system. Male rats (22 day old) were exposed to water containing 0.1% ethanol for control or different concentrations of BPA and its analogues BPB, BPF and BPS (5, 25 and 50 μg/L) in drinking water for 48 weeks. Results of the present study showed a significant alteration in the gonadosomatic index (GSI) and relative reproductive organs weights. Oxidative stress in the testis was significantly elevated while sperm motility, Daily sperm production (DSP) and number of sperm in epididymis were reduced. Plasma testosterone, LH and FSH concentrations were reduced and estradiol levels were high in 50 μg/L exposed group. These results suggest that exposure to BPA and its analogues for chronic duration can induce structural changes in testicular tissue and endocrine alterations in the male reproductive system.

Keywords

Antioxidant enzymes; Bisphenols; Follicle-stimulating hormone; Histology; Luteinizing hormone; Oxidative stress; Testosterone.

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