2. Academic Validation
  3. Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells

Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells

  • Bioorg Chem. 2021 Sep:114:105112. doi: 10.1016/j.bioorg.2021.105112.
Jaeyoung Kwon 1,  Hoseong Hwang 2,  Baskar Selvaraj 2,  Jung Hwan Lee 2,  Woongbi Park 2,  Seung Mok Ryu 3,  Dongho Lee 4,  Jin-Soo Park 2,  Hyoung Seok Kim 2,  Jae Wook Lee 2,  Dae Sik Jang 5,  Hak Cheol Kwon 6
Affiliations

Affiliations

  • 1 KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology (UST), Gangneung 25451, Republic of Korea.
  • 2 KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.
  • 3 Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), Naju 58245, Republic of Korea.
  • 4 Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
  • 5 Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: dsjang@khu.ac.kr.
  • 6 KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea. Electronic address: hkwon@kist.re.kr.
PMID: 34216894 DOI: 10.1016/j.bioorg.2021.105112
Abstract

The consumption of sprouts has been steadily increasing due to their being an excellent source of nutrition. It is known that the bioactive constituents of legumes can be increased after germination. In this study, the extract from Senna tora sprouts is shown to exhibit improved radical scavenging activities and better neuroprotective effects in HT22 hippocampal neuronal (HT22) and R28 retina precursor (R28) cells than those from seeds due to an increased content of phenolic constituents, especially compounds 1 and 3-6. A phytochemical investigation of S. tora sprouts resulted in the isolation of two new naphthopyrone glycosides (1-2) with 27 previously reported compounds. Their structures were determined via interpreting spectroscopic data. Compounds 1 and 3-6 were found to possess radical scavenging activities and neuroprotective effects against oxidative stress in both neuronal cells. Hence, Senna tora sprouts and their constituents may be developed as natural neuroprotective agents via antioxidative effects.

Keywords

Antioxidant; Fabaceae; Naphthopyrone; Neuroprotective effect; Senna tora; Sprout.

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