2. Academic Validation
  3. Production of N-acetylisopenicillin N and isopenicillin N from Streptomyces tokunonensis sp. nov

Production of N-acetylisopenicillin N and isopenicillin N from Streptomyces tokunonensis sp. nov

  • J Antibiot (Tokyo). 1982 Dec;35(12):1646-50. doi: 10.7164/antibiotics.35.1646.
J Shoji,  H Hinoo,  R Sakazaki,  T Kato,  K Matsumoto,  Y Takahashi,  E Kondo
PMID: 7166530 DOI: 10.7164/antibiotics.35.1646
Abstract

N-Acetylisopenicillin N was isolated from the culture broth of Streptomyces tokunonensis sp. nov., and identified from 1H NMR spectroscopy and release of L-alpha-aminoadipic acid by acid hydrolysis. In the course of this study, the specimen of penicillin N isolated from this strain was proved to contain a small amount of isopenicillin N by HPLC.

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