2. Epigenetics PI3K/Akt/mTOR Autophagy Apoptosis
  3. AMPK Autophagy Mitophagy Apoptosis mTOR
  4. Metformin (glycinate)

Metformin (glycinate)  (Synonyms: 1,1-Dimethylbiguanide (glycinate))

目录号: HY-B0627A
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Metformin (1,1-Dimethylbiguanide) glycinate 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin glycinate 也抑制肝脏缺血/再灌注损伤引起的肝脏氧化应激、亚硝化应激、炎症和细胞凋亡 (apoptosis)。此外，Metformin glycinate 还通过激活 AMPK 和抑制 mTOR 信号通路，调节自噬相关蛋白的表达，从而诱导肿瘤细胞自噬 (autophagy) 并抑制体外和体内肾细胞癌生长。

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Metformin (glycinate) Chemical Structure

Metformin (glycinate) Chemical Structure

CAS No. : 121369-64-0

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Metformin (glycinate) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 74 篇科研文献

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    Metformin (glycinate) purchased from MCE. Usage Cited in: Nature. 2025 Feb;638(8052):1112-1121.  [Abstract]

    Metformin (2 mM; 16 h) significantly inhibits the mRNA expression of FOXM1 downstream genes (CDC25B, CCNA2) in HEK293T cells.

    Metformin (glycinate) purchased from MCE. Usage Cited in: Cell Res. 2023 Jul 17.  [Abstract]

    Cells were treated with mannose, MK-8722 (1 μM) or metformin (1 mM) for 6 h. GSDME was immunoprecipitated using anti-GSDME antibody, and then the phosphorylation levels of GSDME T6 were detected.

    Metformin (glycinate) purchased from MCE. Usage Cited in: Front Immunol. 2016 Dec 12;7:597.  [Abstract]

    Metformin increases adenosine triphosphate-induced inflammasome activation in bone marrow-derived macrophages. (A) Cells are treated. Indicated protein levels in both cell lysates and supernatants are evaluated by western blotting. β-Tubulin is used as a loading control for cell lysates. (B–D) The quantitative analyses of the active caspase-1p10 (B), mature interleukin-1β (C), and HMGB1 (D) levels in the supernatants (A) are shown.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Metformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo[1][2][3][4][5][6][7].

    Clinical Trial
    分子量

    204.23

    同用名

    1,1-Dimethylbiguanide (glycinate)

    Formula

    C6H16N6O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Metformin (glycinate) 相关分类

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    Keywords:

    Metformin (glycinate)121369-64-01,1-Dimethylbiguanide (glycinate)AMPKAutophagyMitophagyApoptosismTORAMP-activated protein kinaseMitochondrial AutophagyMammalian target of Rapamycinmitochondrialrespiratorychainliverinsulinsensitivitytype2diabetesblood-brainbarrierInhibitorinhibitorinhibit

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