2. Others Epigenetics PI3K/Akt/mTOR Autophagy Apoptosis
  3. Reference Standards AMPK Autophagy Mitophagy Apoptosis mTOR
  4. Metformin hydrochloride (Standard)

Metformin hydrochloride (Standard)  (Synonyms: 盐酸二甲双胍 (标准品); 1,1-Dimethylbiguanide hydrochloride (Standard))

目录号: HY-17471AR 纯度: 99.97%
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Metformin hydrochloride (Standard) 是 Metformin (hydrochloride) 的分析标准品。本产品用于研究及分析应用。 Metformin hydrochloride (1,1-Dimethylbiguanide) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin hydrochloride 也抑制肝脏缺血/再灌注损伤引起的肝脏氧化应激、亚硝化应激、炎症和细胞凋亡 (apoptosis)。此外，Metformin hydrochloride 还通过激活 AMPK 和抑制 mTOR 信号通路，调节自噬相关蛋白的表达，从而诱导肿瘤细胞自噬 (autophagy) 并抑制体外和体内肾细胞癌生长。

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Metformin hydrochloride (Standard) Chemical Structure

Metformin hydrochloride (Standard) Chemical Structure

CAS No. : 1115-70-4

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规格 价格 是否有货 数量
5 mg ￥620
In-stock
10 mg ￥1000
In-stock
25 mg ￥1800
In-stock
50 mg ￥2700
In-stock
100 mg ￥4050
In-stock
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500 mg   询价  

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生物活性

Metformin hydrochloride (Standard) is the analytical standard of Metformin (hydrochloride). This product is intended for research and analytical applications. Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.

分子量

165.62

Formula

C4H12ClN5
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸二甲双胍 (标准品)；甲福明 (标准品)；降糖片 (标准品)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Metformin hydrochloride (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metformin hydrochloride (Standard)1115-70-41,1-Dimethylbiguanide hydrochloride (Standard)盐酸二甲双胍 (标准品)甲福明 (标准品)降糖片 (标准品)Reference StandardsAMPKAutophagyMitophagyApoptosismTORAMP-activated protein kinaseMitochondrial AutophagyMammalian target of RapamycinInhibitorinhibitorinhibit

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