2. MAPK/ERK Pathway Apoptosis
  3. p38 MAPK c-Myc
  4. Methylcarbamyl PAF C-8

Methylcarbamyl PAF C-8 对 PAF 乙酰水解酶 (PAF-AH) 降解功能具有抗性，在贫血小板血浆中的半衰期超过 100 分钟，具有诱导血小板聚集活性。在过表达 PAF 受体的 NRK-49 细胞中，Methylcarbamyl PAF C-8 能诱导 c-myc、c-fos 表达，并激活丝裂原活化蛋白激酶 (MAPK)，此外，Methylcarbamyl PAF C-8 可诱导 G1 期细胞周期阻滞。Methylcarbamyl PAF C-8 有望用于心血管和抗癌领域的研究。

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Methylcarbamyl PAF C-8 Chemical Structure

Methylcarbamyl PAF C-8 Chemical Structure

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Methylcarbamyl PAF C-8 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methylcarbamyl PAF C-8 is resistant to the degradation function of platelet-activating factor acetylhydrolase (PAF-AH). It has a half-life of more than 100 minutes in platelet-poor plasma and possesses the activity of inducing platelet aggregation. In NRK-49 cells overexpressing the PAF receptor, Methylcarbamyl PAF C-8 can induce the expression of c-myc and c-fos, and activate mitogen-activated protein kinase (MAPK). Additionally, Methylcarbamyl PAF C-8 can induce cell cycle arrest in the G1 phase. Methylcarbamyl PAF C-8 holds promise for research in the fields of cardiovascular diseases and anti-cancer therapy[1].

分子量

426.49

Formula

C18H39N2O7P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methylcarbamyl PAF C-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylcarbamyl PAF C-8Methylcarbamyl PAF C8Methylcarbamyl PAF C 8p38 MAPKc-MycMycInhibitorinhibitorinhibit

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