2. Immunology/Inflammation NF-κB
  3. Interleukin Related NF-κB
  4. MOR-106

MOR-106  (Synonyms: MOR12743; MOR03207)

目录号: HY-P991598
技术支持

MOR-106 (MOR12743) 是一种人源化的抗 IL-17C IgG1 单克隆抗体。MOR-106 通过特异性结合 IL-17C 抑制 NF-κB 信号通路 (对于人源 IL-17C IC50 = 59 pM，对于小鼠 IL-17C IC50 = 55 pM)。MOR-106 可以有效抑制银屑病和特应性皮炎动物模型中的皮肤炎症并减少相关炎症因子。

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MOR-106 Chemical Structure

MOR-106 Chemical Structure

CAS No. : 2304625-87-2

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MOR-106 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
IC50 & Target[1][2]

NF-κB

 

IL-17C

 

体外研究
(In Vitro)

MOR-106 (0.00001-1 nM, 30 分钟) 能有效阻断人 (IC50 = 59 pM) 和小鼠 (IC50 = 55 pM) 的 IL-17C 与 IL-17RE 的相互作用[1]。
MOR-106 (0.0001-1 μg/mL, 30 分钟) 显著抑制 NIH3T3 细胞中 IL-17C 诱导的 NF-κB 信号通路的激活[1]。
MOR-106 (0.001-1 μg/mL, 48 小时) 显著抑制人和小鼠原代角质形成细胞中 IL-17C 和 TNF-α 诱导的 DEFB4A 和 CSF3 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MOR-106 相关抗体:

RT-PCR[1]

Cell Line: human and mouse primary keratinocytes
Concentration: 0.001-1 μg/mL
Incubation Time: 48 h
Result: Significantly reduced the level of DEFB4A and CSF3.
体内研究
(In Vivo)

MOR-106 (10 mg/kg, 腹腔注射, 在首次注射 IL-23前 3 天和注射当天) 显著减少了雌性 BALB/c 小鼠中 IL-23 诱导的皮肤炎症[1]。
MOR-106 (0.4-50 mg/kg, 腹腔注射, 在首次应用 MC903 前 3 天、开始时和后 4 天) 有效缓解了雌性 BALB/c 小鼠中 MC903 诱导的特应性皮炎和特应性湿疹[1][2]。
MOR-106 (3 和 30 mg/kg, 腹腔注射, 每周两次, 持续 6 周) 缓解了 Flaky tail 小鼠的自发性特应性皮炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IL-23 (1 μg, for 4 consecutive days) injeceted female BALB/c mice (8 weeks)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 days before and just before the first injection of IL-23
Result: Significantly reduced ear swelling and epidermal thickening.
Reduced the expression of inflammatory factors such as IL-17A, IL-22, IL-1β, LCN2, S100A8 and S100A9.
Animal Model: Topical administration of 2 nM MC903 (HY-10001) for 5 days to female BALB/c mice (8 weeks)[1][2]
Dosage: 0.4, 2, 10 and 50 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 days before, at the start, and 4 days after the first application of MC903
Result: Dose dependently reduced ear swelling and epidermal thickening.
Reduced TSLP, IL-33, and CCL17 levels.
Significantly reduced skin infiltration of T cells, eosinophils, and neutrophils.
Animal Model: Flaky tail mice on a congenic C57BL/6J background[1]
Dosage: 3 and 30 mg/kg
Administration: Intraperitoneal injection (i.p.), twice weekly for 6 weeks
Result: Significantly reduced skin inflammation score.
Reduced the number of mast cells and serum IgE levels.
Reduced the expression of IL-4, IL-17A, CCL17 and IFN-γ.
基因 ID

27189  [NCBI]

Accession
靶点

IL-17C
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MOR-106 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOR-1062304625-87-2MOR12743 MOR03207MOR106MOR 106MOR 12743MOR-12743MOR03207MOR 03207MOR-03207Interleukin RelatedNF-κBILNuclear factor-κBNuclear factor-kappaBIL-17Cpsoriasisatopic dermatitisInflammationInhibitorinhibitorinhibit

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