2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis c-Met/HGFR PDGFR Src TAM Receptor
  4. Multi-kinase-IN-1

Multi-kinase-IN-1 (Compound 11k) 是一种具有抗肿瘤活性的激酶 (kinase) 抑制剂。Multi-kinase-IN-1 诱导细胞凋亡 (apoptosis)，可用于结直肠癌的研究。

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Multi-kinase-IN-1 Chemical Structure

Multi-kinase-IN-1 Chemical Structure

CAS No. : 2470807-67-9

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Multi-kinase-IN-1 相关抗体

Top Publications Citing Use of Products

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Lck

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer[1].

IC50 & Target

Ron

0.122 μM (IC50)

PDGFRα

0.384 μM (IC50)

c-Src

0.421 μM (IC50)

AXL

0.632 μM (IC50)

体外研究
(In Vitro)

Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 µg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 µg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-kinase-IN-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
Concentration: 0.56, 1.67, and 5 µg/mL for HT-29, 10 µg/mL for FHC
Incubation Time: 0-72 h
Result: Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.

Apoptosis Analysis[1]

Cell Line: HT-29
Concentration: 0.3, 1, and 3 µg/mL
Incubation Time: 0-72 h
Result: Induced cell apoptosis in a time- and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HT-29
Concentration: 0.3, 1, and 3 µg/mL
Incubation Time: 48 h
Result: Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).
分子量

706.76

Formula

C35H36F2N6O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-12470807-67-9Apoptosisc-Met/HGFRPDGFRSrcTAM ReceptorPlatelet-derived growth factor receptorTyro3AxlMerantitumorHT-29low toxicityInhibitorinhibitorinhibit

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