Niacin-¹⁵N,¹³C₃  (Synonyms: 维生素B3-¹⁵N,¹³C₃；烟酸-¹⁵N,¹³C₃；尼克酸-¹⁵N,¹³C₃)

Niacin-¹⁵N,¹³C₃ is the ¹³C and ¹⁵N labeled Niacin[1]. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

127.08

C₃¹³C₃H₅¹⁵NO₂

2483829-87-2

维生素B3-¹⁵N,¹³C₃；烟酸-¹⁵N,¹³C₃；尼克酸-¹⁵N,¹³C₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61.  [Content Brief]

  [3]. Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun164(6):1188-200.  [Content Brief]

  [4]. Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar44(3):209-15.  [Content Brief]

  [5]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.  [Content Brief]

  [6]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar69(3):653-8.  [Content Brief]

  [7]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25103(17):6682-7.  [Content Brief]