2. Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Keap1-Nrf2 Apoptosis Reactive Oxygen Species (ROS)
  4. Nrf2 activator 19

Nrf2 activator 19 是一种通过血脑屏障的 NRF2/HO-1 激活剂，Nrf2 activator 19 发挥出强效抗氧化和神经保护作用。Nrf2 activator 19 还能有效减轻脑损伤，减少 Reactive Oxygen Species (ROS) 积累。Nrf2 activator 19 抑制神经元凋亡 (apoptosis)，促进神经功能和运动能力的恢复。Nrf2 activator 19 在缺血性脑卒中研究中展现出显著潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Nrf2 activator 19 Chemical Structure

Nrf2 activator 19 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Nrf2 activator 19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nrf2 activator 19 is a BBB-penetrable NRF2/HO-1 activator. Nrf2 activator 19 exerts potent antioxidant and neuroprotective effects. Nrf2 activator 19 can also effectively reduce brain damage, reduce Reactive Oxygen Species (ROS) accumulation. Nrf2 activator 19 inhibits neuronal apoptosis. Nrf2 activator 19 promotes the recovery of neurological function and motor ability. Nrf2 activator 19 shows significant potential in ischemic stroke research[1].

体外研究
(In Vitro)

Nrf2 activator 19 (Compound 6p) (40 μM, 24 h) 在 PC12 细胞和 RAW 细胞中未表现出细胞毒性，在 t-BHP 损伤下 PC12 细胞活力可达 90% 以上，体现了很强的保护作用[1]。
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) 在 PC12 细胞中可以有效降低 ROS 水平，并使得丙二醛 (MDA) 水平降低和超氧化物歧化酶 (SOD) 活性升高[1]。
Nrf2 activator 19 (2.5 μM-10 μM, 24 h) 在 PC12 细胞中呈现浓度依赖性方式升高 NRF2 和 HO-1 蛋白的表达。其通过激活 NRF2 通路来对抗氧化损伤[1]。
Nrf2 activator 19 (10 μM, 3 h) 在 PC12 细胞中，降低了 Keap1 表达量，说明与 KEAP1 有直接相互作用[1]。
Nrf2 activator 19 (1.μM, 1 h) 在大鼠肝微粒体中表现出中等代谢稳定性[1]。
Nrf2 activator 19 (10 μM, 24 h) 在基于 Transwell 的 blood-brain barrier (BBB) 模型 (bEnd.3 细胞) 中的渗透率为 7.64%，表明其能够穿过 BBB[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nrf2 activator 19 相关抗体:

Western Blot Analysis[1]

Cell Line: t-BHP (200 μM) treated PC12 cells
Concentration: 2.5 μM-20 μM
Incubation Time: 24 h
Result: Demonstrated that it plays a protective role against oxidative damage by activating the NRF2 pathway, which not only reduced the levels of MDA and ROS, but also increased the expression of SOD and the antioxidant activity is as high as 95% at a concentration of 10 μM.
体内研究
(In Vivo)

Nrf2 activator 19 (5-20 mg/kg, i.v. , 连续 7 天) 在大鼠脑缺血-再灌注损伤 (MCAO) 模型中，改善神经功能恢复，并通过激活 NRF2 通路来对抗缺血-再灌注损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO rat model[1]
Dosage: 5-20 mg/kg
Administration: i.v. , 7 consecutive days
Result: Reduced the infarct area of rats, indicating that it has a protective effect on the nerve damage caused by cerebral ischemia-reperfusion.
Enhanced the expression of NRF2 and HO-1 proteins in the nucleus of rat cerebral ischemia-reperfusion injury (MCAO) model in a concentration-dependent manner, and counteract ischemia-reperfusion injury by activating the NRF2 pathway.
In the Barnes maze experiment, rats were able to find the target box quickly, indicating that it can effectively restore the nerve function of rats.
分子量

400.42

Formula

C25H20O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nrf2 activator 19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator 19Keap1-Nrf2ApoptosisReactive Oxygen Species (ROS)ischemic strokeantioxidantPC12 cellsneuroprotectiveInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Nrf2 activator 19
目录号：
HY-173307
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z