2. Anti-infection Metabolic Enzyme/Protease
  3. SARS-CoV Virus Protease Drug Metabolite
  4. Nsp12-IN-2

Nsp12-IN-2 (Compound 8)，4'-thiouridine (HY-W113081) 的三磷酸代谢产物，是一种 SARS-CoV-2 Nsp12 抑制剂。Nsp12-IN-2 可抑制 SARS-CoV-2 Nsp12-Nsp7-Nsp8 复合物的 RNA 依赖性 RNA 聚合酶 (RdRp) 活性，终止 RNA 合成，并且还能阻止 Nsp9 的 RNA 化和 NMP 化过程。Nsp12-IN-2 有望用于由 SARS-CoV-2、其他冠状病毒以及其他 RNA 病毒引起的感染的研究。

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Nsp12-IN-2 Chemical Structure

Nsp12-IN-2 Chemical Structure

CAS No. : 667882-55-5

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Nsp12-IN-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses[1].

分子量

566.15

Formula

C9H12N2Na3O14P3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nsp12-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nsp12-IN-2667882-55-5SARS-CoVVirus ProteaseDrug MetaboliteSARS coronavirus4'-thiouridineSARS-CoV-2 Nsp12RdRpNsp9infectionsInhibitorinhibitorinhibit

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