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  3. Oxolamine hydrochloride

Oxolamine hydrochloride  (Synonyms: 盐酸奥索拉明)

目录号: HY-B1717A
产品使用指南 技术支持

Oxolamine hydrochloride (SKF-9976 hydrochloride) 是一种具有口服活性止咳剂。Oxolamine hydrochloride 可以抑制 CYP2B1/2。Oxolamine hydrochloride 对豚鼠呼吸器官具有抗炎作用。Oxolamine hydrochloride 增加 Warfarin (HY-B0687) 的 AUC 并延长其终末半衰期。Oxolamine hydrochloride 可用于呼吸道疾病研究。

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Oxolamine hydrochloride Chemical Structure

Oxolamine hydrochloride Chemical Structure

CAS No. : 1219-20-1

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Customer Review

Other Forms of Oxolamine hydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxolamine hydrochloride (SKF-9976 hydrochloride) is an orally active antitussive. Oxolamine hydrochloride can inhibit CYP2B1/2. Oxolamine hydrochloride has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine hydrochloride increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine hydrochloride can be used in respiratory disease research[1][2][3][4].

IC50 & Target[1][2][3][4]

CYP2B1

 

CYP2B2

 

体外研究
(In Vitro)

Oxolamine (10 μg/mL;24 h) hydrochloride 显著降低新鲜大鼠血浆中 Clarithromycin (HY-17508) 的血浆蛋白结合率[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Oxolamine (Oxolamine citrate;10-50 mg/kg;口服;每日 3 次,连续 3 天) hydrochloride 显著增加雄性 SD 大鼠中 Warfarin (HY-B0687) 的 AUC 并延长其终末半衰期[3]
Oxolamine (Oxolamine citrate;初始剂量 80 mg/kg 体重,随后 53.3 mg/kg 腹腔注射;共 11 次,分别于 3、6、9、24、28、32、48、52、56、72 和 76 h 给药) hydrochloride 对豚鼠呼吸器官表现出明显的抗炎作用[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pigs + non-bacterial inflammation of the respiratory tract model induced by inhalation of acrolein aerosol[4]
Dosage: 80 mg/kg body weight initially, then 53.3 mg/kg
Administration: Intraperitoneal injection, 11 times at 3, 6, 9, 24, 28, 32, 48, 52, 56, 72 and 76 h
Result: Reduced relative lung weight.
Significantly reduced inflammation levels.
Protected the pulmonary parenchyma from emphysema.
Showed anti-inflammatory effect superior to that of Phenylbutyrone.
分子量

281.78

同用名

盐酸奥索拉明

Formula

C14H20ClN3O

CAS 号
中文名称

盐酸奥索拉明;奥索拉明盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Oxolamine hydrochloride
目录号:
HY-B1717A
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