Oxolamine hydrochloride  (Synonyms: 盐酸奥索拉明)

Oxolamine hydrochloride (SKF-9976 hydrochloride) is an orally active antitussive. Oxolamine hydrochloride can inhibit CYP2B1/2. Oxolamine hydrochloride has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine hydrochloride increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine hydrochloride can be used in respiratory disease research^[1][2][3][4].

Oxolamine (10 μg/mL；24 h) hydrochloride 显著降低新鲜大鼠血浆中 Clarithromycin (HY-17508) 的血浆蛋白结合率^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxolamine (Oxolamine citrate；10-50 mg/kg；口服；每日 3 次，连续 3 天) hydrochloride 显著增加雄性 SD 大鼠中 Warfarin (HY-B0687) 的 AUC 并延长其终末半衰期^[3]。
Oxolamine (Oxolamine citrate；初始剂量 80 mg/kg 体重，随后 53.3 mg/kg 腹腔注射；共 11 次，分别于 3、6、9、24、28、32、48、52、56、72 和 76 h 给药) hydrochloride 对豚鼠呼吸器官表现出明显的抗炎作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

281.78

盐酸奥索拉明

C₁₄H₂₀ClN₃O

1219-20-1

盐酸奥索拉明；奥索拉明盐酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kirilmaz L, et, al. Sustained-release dosage form of oxolamine citrate: preparation and release kinetics. J Microencapsul. Apr-Jun 1992;9(2):167-72.  [Content Brief]

  [2]. GIUDICI G, et, al. [On the anti-inflammatory action of oxolamine citrate]. Minerva Med. 1961 Oct 31;52:3752-5.  [Content Brief]

  [3]. Zhu X, et al. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28(3):125-33.  [Content Brief]

  [4]. Dahlgren S, et al. The effect of oxolamine citrate on experimentally produced inflammation in the respiratory organs. Acta Pharmacol Toxicol (Copenh). 1966;24(2):286-96.  [Content Brief]