2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. p27 Analogue CP2

p27 Analogue CP2 是一种大环肽抑制剂，靶向 SCFSkp2/Cks1 E3 蛋白质降解酶复合体 (Kd=32 nM)。p27 Analogue CP2 能够阻止 SCFSkp2/Cks1 介导的 p27 蛋白的泛素化和降解，恢复 p27 的水平并抑制细胞增殖。p27 Analogue CP2 有望用于依赖于 Skp2 过度表达的癌症的研究，如乳腺癌。

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Custom Peptide Synthesis

p27 Analogue CP2 Chemical Structure

p27 Analogue CP2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

p27 Analogue CP2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the SCFSkp2/Cks1 E3 ubiquitin ligase (Kd=32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer[1].

分子量

1341.33

Formula

C52H85N20O20P
Sequence

Ala-Gly-Ser-{X2}-Glu-Gln-Thr{phos}-Pro-{X3}-Lys
Sequence Shortening

AGS-{X2}-EQT-{phos}-P-{X3}-K
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p27 Analogue CP2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p27 Analogue CP2E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSCFSkp2/Cks1 E3 ubiquitin ligasecell proliferationbreast cancerInhibitorinhibitorinhibit

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产品名称：
p27 Analogue CP2
目录号：
HY-P11020
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