2. Cell Cycle/DNA Damage
  3. p97
  4. p97-IN-1

p97-IN-1 是一种口服有效的 p97 抑制剂 (IC50 = 26 nM)。p97-IN-1 能明显抑制肿瘤细胞的增殖。p97-IN-1 可用于急性髓系白血病 (AML) 的研究。

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p97-IN-1 Chemical Structure

p97-IN-1 Chemical Structure

CAS No. : 3007658-96-7

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p97-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p97-IN-1 is an orally active p97 inhibitor (IC50 = 26 nM). p97-IN-1 can significantly inhibit the proliferation of tumor cells. p97-IN-1 can be used for research on acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

p97-IN-1 (Compound V12) (0-10 μM，72 小时) 可以抑制多种肿瘤细胞系的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

p97-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: RPMI-8226, HCT-116, BXPC-3, SV620, ARP1, H929, MM-15, KMS-11, MV-4-11, Molm-13 and Molm-16 cells
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Significantly inhibited the proliferation of various tumor cell lines, including RPMI-8226 (IC50 = 0.5 μM), HCT-116 (IC50 = 0.7 μM), BXPC-3 (IC50 = 1.4 μM), SV620 (IC50 = 2.3 μM), ARP1 (IC50 = 2.1 μM), H929 (IC50 = 0.7 μM), KMS-11 (IC50 = 2.1 μM), MV-4-11 (IC50 = 0.4 μM), Molm-13 (IC50 = 1.4 μM) and Molm-1 6(IC50 = 0.4 μM) cells.
体内研究
(In Vivo)

p97-IN-1 (Compound V12) (100 mg/kg and 300mg/kg; 口服; 每日一次) 在 Molm-13 异种移植肿瘤的雌性 BALB/c 裸鼠中显著抑制肿瘤生长且在高剂量下没有观察到明显的毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice (6-8 weeks, 18-22 g) bearing 5×106 Molm-13 cells xenograft tumor[1]
Dosage: 100 mg/kg or 300 mg/kg
Administration: Oral administration (p.o.); once daily
Result: Significantly reduced tumor volume.
Did not significantly alter the weight of the mice.
分子量

442.51

Formula

C25H26N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p97-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p97-IN-13007658-96-7p97VCPCdc48VCP/p97AMLinhibitorcancerLeukemiaInhibitorinhibit

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