2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP-2-IN-2

PARP-2-IN-2 (compound 27) 是 PARP‑2 的抑制剂，IC50 值为 0.057 µM。PARP-2-IN-2 诱导 MCF-7 乳腺癌细胞周期阻滞和凋亡。PARP-2-IN-2 可用于癌症的研究。

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PARP-2-IN-2 Chemical Structure

PARP-2-IN-2 Chemical Structure

CAS No. : 2915651-00-0

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PARP-2-IN-2 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP-2-IN-2 (compound 27) is a PARP‑2 inhibitor with an IC50 value of 0.057 µM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer[1].
IC50 & Target

IC50: 0.057 µM (PARP‑2), 11.32 µM (MDA-MB-231 cells), 16.70 µM (MCF-7 cells)[1]
体外研究
(In Vitro)

PARP-2-IN-2 (0-1 μM; 1 h) inhibits PARP‑2 with an IC50 value of 0.057 µM[1].
PARP-2-IN-2 (0-100 μM; 24 h) shows cytotoxicity to MDA-MB-231 and MCF-7 cancer cells[1].
PARP-2-IN-2 (16.7 μM; 24 h) induces cell cycle arrest and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PARP-2-IN-2 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 and MCF-7 cell lines
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed in vitro cytotoxicity to MDA-MB-231 and MCF-7 cells with IC50 values of 11.32 and 16.70 µM, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 16.70 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G1/S phase with cells in pre-G1 phase increased from 1.85 to 25.91%.

Apoptosis Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 16.70 µM
Incubation Time: 24 h
Result: Induced potent apoptotic and weak necrotic effect in MCF-7 breast cancer cell line.
分子量

371.86

Formula

C20H22ClN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP-2-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-2-IN-22915651-00-0PARPApoptosispoly ADP ribose polymerase benzoxazole derivativebreast cancersorafenibolaparibcell cycle arrestapoptosisnecroticInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-151624
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