2. Immunology/Inflammation
  3. CD3
  4. Pasotuxizumab

Pasotuxizumab  (Synonyms: BAY 2010112; AMG 212)

目录号: HY-P99802 纯度: 98.02%
COA

摩尔计算器

Pasotuxizumab (BAY 2010112) 是一种 PSMA 和 CD3 双特异性的 T 细胞接合剂 (BiTE)。Pasotuxizumab 可结合 CD3 和 PSMA，对人 CD3 和 PSMA 的 KD 分别为 9.4 nM 和 47.0 nM。Pasotuxizumab 可用于转移性去势抵抗性前列腺癌 (mCRPC) 的研究。

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Pasotuxizumab Chemical Structure

Pasotuxizumab Chemical Structure

CAS No. : 1442657-12-6

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Pasotuxizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2].

IC50 & Target

KDs: 9.4 nM and 16.3 nM for human and cynomolgus monkey CD3.
KDs: 47.0 nM and 212.6 nM for human and cynomolgus monkey PSMA.
体外研究
(In Vitro)

Pasotuxizumab (约 0-100 ng/mL，48 小时) 可激活 CD4+ 和 CD8+ T 细胞群，EC50 为 3.4-6.7 ng/mL (人) 和 13.7-21.2 ng/mL (食蟹猴)[2]。
Pasotuxizumab (约 0-100 ng/mL，48 小时) 增加 T 细胞中干扰素-γ、TNF-α、IL-2 和 IL-10 的释放[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pasotuxizumab 相关抗体:
体内研究
(In Vivo)

Rafivirumab (0.005-5 mg/kg，尾静脉注射，每日一次) 抑制 PC-3-huPSMA 小鼠异种移植模型中的肿瘤生长[2]。
Rafivirumab (0.1-1 mg/kg，静脉推注给药) 在 BALB/c 小鼠中表现出较低的血清清除率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PC-3-huPSMA mouse xenograft model[2]
Dosage: 0.005-5 mg/kg
Administration: i.v., once daily
Result: Inhibited tumor growth by 86% (0.005 mg/kg/d) and 99% (5 mg/kg/d).
Animal Model: BALB/c mice (PK Assay)[2]
Dosage: 0.1, 0.3, and 1 mg/kg
Administration: i.v. bolus administration or s.c.
Result: Pharmacokinetic profile of Rafivirumab.
Dose (mg/kg) AUC (mg h/L) CLmatrix (L/h/kg) T1/2 (h) F (%)
i.v. (0.3) 0.93 0.32 9.7 100
s.c. (0.3) 0.17 11 18
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pasotuxizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pasotuxizumab1442657-12-6BAY 2010112 AMG 212BAY2010112BAY-2010112AMG212AMG 212AMG-212CD3Cluster of differentiation 3mCRPCcancerT-cellBiTEPC-3prostate cancerInhibitorinhibitorinhibit

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