2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphodiesterase (PDE) NAMPT Apoptosis
  4. PDEδ/NAMPT IN-1

PDEδ/NAMPT IN-1 (Compound 17d) 是一种靶向磷酸二酯酶 6 (PDE6) (KD=0.410 nM) 和烟酰胺磷酸核糖转移酶 (NAMPT) (IC50=2.21 nM) 的双重抑制剂。PDEδ/NAMPT IN-1 阻断 KRAS 相关信号传导，抑制 NAMPT 干扰烟酰胺腺嘌呤二核苷酸 (NAD+) 的合成，诱导 KRAS 突变胰腺癌细胞凋亡 (apoptosis)。PDEδ/NAMPT IN-1 有望用于 KRAS 突变型胰腺癌的研究。

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PDEδ/NAMPT IN-1 Chemical Structure

PDEδ/NAMPT IN-1 Chemical Structure

CAS No. : 2976498-55-0

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PDEδ/NAMPT IN-1 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer[1].

IC50 & Target

PDE6

0.41 nM (Kd)

分子量

494.61

Formula

C26H30N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDEδ/NAMPT IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

PDEδ/NAMPT IN-12976498-55-0Phosphodiesterase (PDE)NAMPTApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorPDE6KRAS mutant pancreatic cancerInhibitorinhibitorinhibit

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