1. Metabolic Enzyme/Protease
  2. Nampt


Nampt (Nicotinamide phosphoribosyl transferase) has been reported to be a cytokine that promotes B cell maturation and inhibits neutrophil apoptosis. NAmPRTase catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Nampt 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-50876
    (E)-Daporinad Inhibitor 99.91%
    (E)-Daporinad (FK866) 是烟酰胺磷酸核糖转移酶 (NMPRTase) 的有效抑制剂, IC50 为 0.09 nM。
  • HY-15976
    P7C3 Activator 99.97%
  • HY-12808
    STF-118804 Inhibitor 98.55%
    STF-118804是烟酰胺磷酸核糖基转移酶Nampt高选择性抑制剂,细胞viability IC50小于10nM。
  • HY-10079
    CHS-828 Inhibitor 99.72%
  • HY-12793
    KPT-9274 Inhibitor 99.28%
    KPT-9274 is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s less than 100 and 120 nM, respectively.
  • HY-112616
    NAMPT inhibitor-linker 2 Inhibitor
    NAMPT inhibitor-linker 2 为 ADC 的一部分,由一种 NAMPT 的抑制剂作为有效载荷和一个连接物组成。ADC-4 由一个 NAMPT inhibitor-linker 2 和一个 anti-c-Kit 单克隆抗体组成,对表达 c-Kit 的细胞具有抑制作用,比如 GIST-T1 和 NCI-H526 细胞,IC50 值分别为 <7 pM 和 40 pM。
  • HY-112615
    NAMPT inhibitor-linker 1 Inhibitor
    NAMPT inhibitor-linker 1 为 ADC 的一部分,由一种 NAMPT 的抑制剂作为有效载荷和一个连接物组成。ADC-3 由一个 NAMPT inhibitor-linker 1 和一个 anti-c-Kit 单克隆抗体组成,对表达 c-Kit 的细胞具有抑制作用,比如 GIST-T1 和 NCI-H526 细胞,IC50 值分别为 <3 pM 和 9 pM。
  • HY-15766
    GNE-617 Inhibitor 99.46%
  • HY-12971
    Nampt-IN-1 Inhibitor 99.12%
    Nampt-IN-1 (LSN3154567) 是一种有效的选择性 NAMPT 抑制剂。Nampt-IN-1 抑制纯化的 NAMPT,IC50 为 3.1 nM。
  • HY-15766A
    GNE-617 hydrochloride Inhibitor 98.83%
    GNE-617 hydrochloride 是一种特异性的 NAMPT 抑制剂,抑制 NAMPT 活性,IC50 为 5 nM。
  • HY-14375
    CB 300919 Inhibitor 99.01%
    CB 300919是CB30865的水溶性类似物,对人CH1卵巢癌外植体的IC50为2 nM。
  • HY-14373
    CB30865 Inhibitor 98.33%
    CB30865(ZM 242421)是Nampt抑制剂。
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