2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. PDGFRα kinase inhibitor 3

PDGFRα kinase inhibitor 3 (Compound L7) 是一种靶向 PDGFRαD842V 激酶的强效抑制剂，在生化和细胞分析中的 IC50 值分别为 23.8 nM 和 2.1 nM。PDGFRα kinase inhibitor 3 与PDGFRαD842V 的 ATP 结合位点结合，从而阻断其下游信号通路并抑制激酶活性。PDGFRα kinase inhibitor 3 可用于胃肠道间质瘤 (GIST) 的研究。

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PDGFRα kinase inhibitor 3 Chemical Structure

PDGFRα kinase inhibitor 3 Chemical Structure

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PDGFRα kinase inhibitor 3 相关抗体

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDGFRα kinase inhibitor 3 (Compound L7) is a highly potent inhibitor targeting the PDGFRαD842V kinase with IC50s values of 23.8 nM and 2.1 nM in biochemical and cellular assays, respectively. PDGFRα kinase inhibitor 3 binds to the ATP-binding pocket of PDGFRαD842V to block its downstream signaling pathways and inhibit kinase activity. PDGFRα kinase inhibitor 3 can be used for gastrointestinal stromal tumors (GISTs) study[1].

IC50 & Target

IC50: PDGFRαD842 V/G680R (64.1 nM), PDGFRαD842 V/T674I (27.6 nM)
分子量

385.46

Formula

C23H23N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDGFRα kinase inhibitor 3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDGFRα kinase inhibitor 3PDGFRα kinase inhibitor3PDGFRα kinase inhibitor-3PDGFRPlatelet-derived growth factor receptorGISTtumorkinaseBa/F3 cellsInhibitorinhibitorinhibit

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产品名称：
PDGFRα kinase inhibitor 3
目录号：
HY-173275
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