2. Cell Cycle/DNA Damage Anti-infection
  3. Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog
  4. Pseudouridimycin

Pseudouridimycin  (Synonyms: PUM)

目录号: HY-125650 纯度: ≥96.0%
COA 产品使用指南 技术支持

Pseudouridimycin (PUM) 是一种选择性抑制细菌 RNA 聚合酶 (RNAP) 的抗生素 (antibiotic)，其 IC50 约为 0.1 μM，MIC 为 4-6 μg/mL。Pseudouridimycin 是一种 C-核苷类似物，对革兰氏阴性菌和革兰氏阳性菌均有效。Pseudouridimycin 在体外可抑制细菌生长，并在小鼠化脓性链球菌性腹膜炎模型中显示出活性。

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Pseudouridimycin Chemical Structure

Pseudouridimycin Chemical Structure

CAS No. : 1566586-52-4

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Pseudouridimycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].

体外研究
(In Vitro)

Pseudouridimycin (PUM) 具有选择性，因为它的侧链结合在细菌 RNA 聚合酶中保守的区域，但在人类中不保守。Pseudouridimycin (PUM) 对药物敏感、耐药和多重耐药的链球菌具有体外杀菌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pseudouridimycin 相关抗体:
体内研究
(In Vivo)

Pseudouridimycin (3.2-50 mg/kg；静脉注射；感染后10分钟，感染后6小时再次注射) 可清除小鼠化脓性链球菌腹膜炎模型中的体内感染 (ED50 = 9 mg/kg)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3].
Dosage: 3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg
Administration: iv; 10 min after infection and again 6 h after infection
Result: Showed antibacterial activity in vivo.
分子量

486.44

同用名

PUM

Formula

C17H26N8O9
CAS 号
性状

固体

颜色

Off-white to light yellow

结构分类
初始来源

treptomyces sp
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥96.0%

COA (289 KB)

产品使用指南 (1538 KB)
参考文献

Pseudouridimycin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseudouridimycin1566586-52-4PUMAntibioticDNA/RNA SynthesisBacterialNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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