2. Metabolic Enzyme/Protease
  3. Proteasome
  4. PSI TFA

PSI TFA  (Synonyms: Proteasome Inhibitor 1 TFA; Z-Ile-Glu(OtBu)-Ala-Leu-CHO TFA)

目录号: HY-P1258A
产品使用指南

摩尔计算器

PSI (TFA) 是一种有效的蛋白酶体 proteasome 抑制剂。PSI (TFA) 抑制原发性渗出性淋巴瘤 (PEL) 细胞的增殖。PSI (TFA) 可用于卡波济氏肉瘤相关疱疹病毒 (KSHV) 感染和 KSHV 相关淋巴瘤的研究。

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Custom Peptide Synthesis

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PSI TFA Chemical Structure

PSI TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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PSI TFA 的其他形式现货产品:

PSI

Customer Review

Other Forms of PSI TFA:

PSI TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PSI (TFA) is a potent proteasome inhibitor. PSI (TFA) inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI (TFA) can be used for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1].

IC50 & Target

CC50: 205 nM (BJAB cells); 190 nM (Ramos cells); 22.0 nM (BC3 cells); 53.0 nM (BCBL1 cells)[1]
体外研究
(In Vitro)

PSI (TFA) (24 h) inhibits the proliferation with CC50 values of 205, 190, 22.0, 53.0 nM for BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].
PSI (TFA) (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].
PSI (TFA) (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].
PSI (TFA) (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PSI TFA 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: BC3, BCBL1, Ramos, BJAB cells
Concentration:
Incubation Time: 24 h
Result: Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50 values of 205, 190, 22.0, 53.0 nM for BJAB, Ramos, BC3, BCBL1 cells, respectively).

Western Blot Analysis[1]

Cell Line: HBL6 cells
Concentration: 50 nM
Incubation Time: 6 h
Result: Decreased the NF-κB activity by 52%.
Clinical Trial
分子量

732.78

Formula

C34H51F3N4O10
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PSI TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSIProteasome Inhibitor 1Z-Ile-Glu(OtBu)-Ala-Leu-CHOProteasome Inhibitor1Proteasome Inhibitor-1ProteasomePrimary effusion lymphoma (PEL)apoptosisHBL6 cellsBC3 cellsNF-κBKSHVInhibitorinhibitorinhibit

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