1. Metabolic Enzyme/Protease
  2. Proteasome

Proteasome

Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into amino acids and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Proteasome 相关产品 (27):

Cat. No. Product Name Effect Purity
  • HY-13259
    MG-132 Inhibitor >98.0%
    MG-132是一种有效,可逆,能渗透细胞的 20S蛋白酶体 抑制剂。它抑制蛋白酶体胰凝乳蛋白酶样肽酶活性的 IC50值为 24.2 nM。
  • HY-10227
    Bortezomib Inhibitor 99.97%
    Bortezomib 是有效的 20S 蛋白酶体 (20S proteasome) 抑制剂,Ki 为 0.6 nM。
  • HY-10455
    Carfilzomib Inhibitor 99.26%
    Carfilzomib是不可逆的蛋白酶体 (proteasome) 抑制剂,其在ANBL-6和RPMI 8226细胞中的 IC50 为5 nM。
  • HY-B0496
    PMSF Inhibitor >99.0%
    PMSF是通常用于制备细胞裂解物的不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。
  • HY-13067
    Celastrol Inhibitor 99.90%
    Celastrol是一种蛋白酶体抑制剂,有效且优先抑制20S 蛋白酶体的胰凝乳蛋白酶样活性,IC50 为2.5 μM。
  • HY-101286
    Rpn11-IN-1 Inhibitor
    Rpn11-IN-1 是一种有效的选择性蛋白酶体亚基 Rpn11 抑制剂,IC50 为 390 nM。
  • HY-100227
    E 64c Inhibitor
    E 64c 是半胱氨酸蛋白酶 (cysteine proteases) 天然环氧化物抑制剂的衍生物,也是钙离子激活中性蛋白酶 (CANP) 的抑制剂和组织蛋白酶C (cathepsin C) 的弱不可逆抑制剂。
  • HY-13207
    ONX-0914 Inhibitor 98.86%
    ONX-0914 (PR-957)是免疫蛋白酶体抑制剂,与其它蛋白酶体的交叉反应极小。
  • HY-P0018
    Pepstatin Inhibitor 98.45%
    Pepstatin is a specific aspartic proteases inhibitor produced by actinomycetes, and also inhibits HIV protease. Sequence: Isovaleryl-Val-Val-Sta-Ala-Sta-OH.
  • HY-13821
    Epoxomicin Inhibitor 99.89%
    Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。
  • HY-10453
    Ixazomib Inhibitor >98.0%
    MLN2238 是一种有效的选择性的可逆蛋白酶体 (proteasome)抑制剂,抑制20S蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50 为 3.4 nM,Ki 为 0.93 nM。
  • HY-18964
    MG-101 Inhibitor
    MG-101是有效的半胱氨酸蛋白酶抑制剂,抑制钙蛋白酶I,钙蛋白酶II,组织蛋白酶B和组织蛋白酶L的Ki分别为190,220,150和500 pM。
  • HY-P0018A
    Pepstatin Trifluoroacetate Inhibitor 99.11%
    Pepstatin Trifluoroacetate 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,同时可抑制 HIV protease 的活性。
  • HY-10452
    Ixazomib citrate Inhibitor >98.0%
    MLN2238是 20S蛋白酶体胰凝乳蛋白酶样蛋白水解β5位点的可逆抑制剂,IC50 为3.4 nM和Ki为0.93 nM。
  • HY-12113
    Oprozomib Inhibitor 99.60%
    Oprozomib (ONX 0912; PR047)是口服生物相容性的抑制剂,能抑制20S proteasome(20S蛋白酶体)β5/LMP7的CT-L活性,IC50为36 nM/82 nM。
  • HY-100529
    PD150606 Inhibitor >98.0%
    PD 150606是一个选择性的,能穿过细胞的非肽calpain抑制剂。
  • HY-10454
    Delanzomib Inhibitor >98.0%
    Delanzomib(CEP-18770)是口服活性的蛋白酶体糜蛋白酶样活性抑制剂,能下调核内NF-kappaB活性。
  • HY-100739
    RA190 Inhibitor 98.03%
    RA190是双亚苄基哌啶,通过与泛素受体RPN13的半胱氨酸88共价结合来抑制蛋白酶体功能。
  • HY-110404
    Capzimin Inhibitor 99.19%
    Capzimin是有效的,特异性适中的,蛋白酶体异肽酶 Rpn11 抑制剂。
  • HY-18741
    VR23 Inhibitor
    VR23有效抑制胰蛋白酶样蛋白酶 (IC50=1nM), 胰凝乳蛋白酶样蛋白酶 (IC50 =50-100 nM), 和caspase样蛋白酶 (IC50 =3μM)。
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