1. Metabolic Enzyme/Protease
  2. Proteasome


Proteasomes are very large protein complexes inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, they are located in the nucleus and the cytoplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into amino acids and used in synthesizing new proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.

Proteasome 相关产品 (23):

Cat. No. Product Name Effect Purity
  • HY-13259
    MG-132 Inhibitor >98.0%
    MG-132 是一种有效的非特异性的 20S 蛋白酶体(20S proteasome)抑制剂,作用于 β5 糜蛋白酶样 (β5 chymotrypsin) 活性位点,IC50 为 24.2 nM。
  • HY-10227
    Bortezomib Inhibitor 99.71%
    Bortezomib 是一种有效的 20S 蛋白酶体 (20S proteasome) 抑制剂,Ki 为 0.6 nM。
  • HY-10455
    Carfilzomib Inhibitor 99.44%
    Carfilzomib 是一种 proteasome 的不可逆抑制剂,在 ANBL-6 和 RPMI 8226 细胞中,IC50 值 < 5 nM。
  • HY-13067
    Celastrol Inhibitor 99.90%
    Celastrol 是一种蛋白酶体 (proteasome) 抑制剂,有效且优先抑制纯化的 20S蛋白酶体 (20S proteasome) 糜蛋白酶样活性 (IC50=2.5 μM)。
  • HY-B0496
    PMSF Inhibitor 99.24%
    PMSF 是一种不可逆的 serine/cysteine protease 抑制剂。
  • HY-N0375
    18α-Glycyrrhetinic acid Activator 99.19%
    18α-甘草次酸是 NF-kB 的抑制剂和蛋白酶体的激活剂。
  • HY-100172
    Proteasome-IN-1 Inhibitor
    Proteasome-IN-1 是一个蛋白酶体抑制剂,来自专利 WO 2013142376 A1。
  • HY-100193
    FK-448 Free base Inhibitor
    FK-448 Free base 是一种有效的,特异性的糜蛋白酶 (chymotrypsin) 抑制剂,IC50 值为 720 nM。
  • HY-13821
    Epoxomicin Inhibitor 99.89%
  • HY-10453
    MLN2238 Inhibitor 99.07%
    MLN2238 是一种有效的选择性的可逆蛋白酶体 (proteasome)抑制剂,抑制20S蛋白酶体的糜蛋白酶样蛋白水解 (β5) 位点,IC50 为 3.4 nM,Ki 为 0.93 nM。
  • HY-18964
    MG-101 Inhibitor
    MG-101是一种有效的半胱氨酸蛋白酶抑制剂, 作用于钙蛋白酶I, 钙蛋白酶II, 组织蛋白酶B, 和组织蛋白酶L, Ki值分别为190 nM , 220 nM, 150 nM, 500 pM.
  • HY-10452
    MLN9708 Inhibitor 99.87%
    MLN2238 能够迅速水解成 MLN2238,是有效的蛋白酶 (proteasome) 抑制剂,能够抑制 20S 蛋白酶蛋白水解位点 β5,IC50 值为 3.4 nM,Ki 值为 0.93 nM;同时可抑制 β1 和 β2 这两个蛋白水解位点,IC50 值分别为 31 和 3500 nM。
  • HY-12113
    Oprozomib Inhibitor 99.60%
    Oprozomib (ONX 0912; PR047)是口服生物相容性的抑制剂,能抑制20S proteasome(20S蛋白酶体)β5/LMP7的CT-L活性,IC50为36 nM/82 nM。
  • HY-13207
    ONX-0914 Inhibitor 98.16%
    ONX-0914 (PR-957)是免疫蛋白酶体抑制剂,与其它蛋白酶体的交叉反应极小。
  • HY-100529
    PD150606 Inhibitor >98.0%
    PD 150606是一个选择性的,能穿过细胞的非肽calpain抑制剂。
  • HY-10454
    Delanzomib Inhibitor
  • HY-18741
    VR23 Inhibitor 99.33%
    VR23有效抑制胰蛋白酶样蛋白酶 (IC50=1nM), 胰凝乳蛋白酶样蛋白酶 (IC50 =50-100 nM), 和caspase样蛋白酶 (IC50 =3μM)。
  • HY-100739
    RA190 Inhibitor 98.03%
  • HY-B0385
    Gabexate mesylate Inhibitor 98.51%
  • HY-12286
    PI-1840 Inhibitor 98.62%
    PI-1840是蛋白酶体chymotrypsin-like (CT-L)高效选择性性抑制剂,IC50值为27nM。