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  4. PTC258

PTC258 是一种特异性的、口服活性的伸长复合体蛋白 1 基因 (ELP1) 基因剪接调节剂。PTC258 在体外和体内均能增加 ELP1 的表达。PTC258 在小鼠模型中具有良好的耐受性。

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PTC258 Chemical Structure

PTC258 Chemical Structure

CAS No. : 2476724-74-8

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规格 价格 是否有货 数量
1 mg ￥1800
In-stock
5 mg ￥4500
In-stock
10 mg ￥7100
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

PTC258 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model[1].

体外研究
(In Vitro)

PTC258 (0.01 nM-0.01 μM; 48 h) efficiently increases full-length ELP1 mRNA and protein in Familial Dysautonomia (FD) patient fibroblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PTC258 相关抗体:
体内研究
(In Vivo)

PTC258 (3-24 mg/kg; p.o.; once daily for 3 months) is well tolerated. It corrects the splicing of the ELP1 transcript and significantly increases the amount of functional protein in vivo in all tissues tested, including the brain in mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Familial Dysautonomia (FD) Mouse model[1]
Dosage: 3 mg/kg, 6 mg/kg, 12 mg/kg, 24 mg/kg
Administration: Oral gavage; once daily for 3 month
Result: Increased full-length ELP1 transcript in a dose-dependent manner. And also, it increased in functional ELP1 protein in the brain, trigeminal, liver, and quadricep.
分子量

351.92

Formula

C16H18ClN3S2
CAS 号
性状

固体

颜色

White to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (284.16 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8416 mL 14.2078 mL 28.4155 mL
5 mM 0.5683 mL 2.8416 mL 5.6831 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PTC258 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8416 mL 14.2078 mL 28.4155 mL 71.0389 mL
5 mM 0.5683 mL 2.8416 mL 5.6831 mL 14.2078 mL
10 mM 0.2842 mL 1.4208 mL 2.8416 mL 7.1039 mL
15 mM 0.1894 mL 0.9472 mL 1.8944 mL 4.7359 mL
20 mM 0.1421 mL 0.7104 mL 1.4208 mL 3.5519 mL
25 mM 0.1137 mL 0.5683 mL 1.1366 mL 2.8416 mL
30 mM 0.0947 mL 0.4736 mL 0.9472 mL 2.3680 mL
40 mM 0.0710 mL 0.3552 mL 0.7104 mL 1.7760 mL
50 mM 0.0568 mL 0.2842 mL 0.5683 mL 1.4208 mL
60 mM 0.0474 mL 0.2368 mL 0.4736 mL 1.1840 mL
80 mM 0.0355 mL 0.1776 mL 0.3552 mL 0.8880 mL
100 mM 0.0284 mL 0.1421 mL 0.2842 mL 0.7104 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTC2582476724-74-8PTC 258PTC-258OthersInhibitorinhibitorinhibit

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产品名称：
PTC258
目录号：
HY-148772
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