1. NF-κB Apoptosis
  2. NF-κB Apoptosis
  3. PTD-p65-P1 Peptide

PTD-p65-P1 Peptide 是一种有效的选择性核转录因子 NF-κB 抑制剂,来源于 NF-κB 氨基酸残基 271-282 的 p65 亚单位,可选择性抑制各种炎症刺激诱导的 NF-κB 激活,下调 NF-κB 介导的基因表达,并上调细胞凋亡(apoptosis)。

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Custom Peptide Synthesis

PTD-p65-P1 Peptide Chemical Structure

PTD-p65-P1 Peptide Chemical Structure

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PTD-p65-P1 Peptide 的其他形式现货产品:

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Other Forms of PTD-p65-P1 Peptide:

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查看 NF-κB 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis[1][2].

IC50 & Target

NF-kappaB[1]

体外研究
(In Vitro)

PTD-p65-P1 Peptide (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM[1].
PTD-p65-P1 Peptide (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation[1].
PTD-p65-P1 Peptide (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%[1].
PTD-p65-P1 Peptide (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF[1].
PTD-p65-P1 Peptide (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: KBM-5 cells
Concentration: 150 μM
Incubation Time: 0, 5, 10, 15, 30 and 60 minutes
Result: Suppressed TNF-induced NF-κB activation by inhibiting phosphorylation and nuclear translocation of p65.

Cell Viability Assay[2]

Cell Line: SP-53 cells
Concentration: 150 μM
Incubation Time: 12 and 24 hours
Result: Inhibited cell proliferation of 40% in 12 hours and 60% in 24 hours.
分子量

3829.50

Formula

C168H275N57O44S

Sequence Shortening

DRQIKIWFQNRRMKWKKQLRRPSDRELSE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

PTD-p65-P1 Peptide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PTD-p65-P1 Peptide
目录号:
HY-P1832
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