2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Apoptosis Anti-infection
  3. Potassium Channel Cytochrome P450 Apoptosis Parasite
  4. Quinidine polygalacturonate

Quinidine polygalacturonate  (Synonyms: 奎尼丁聚半乳糖酸酯)

目录号: HY-B1751E
产品使用指南

摩尔计算器

Quinidine polygalacturonate 是一种抗心律失常剂。Quinidine polygalacturonate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+ 通道 (K+ channel) 的有效阻断剂，其 IC50 值为 19.9 μM，也可诱导凋亡。Quinidine polygalacturonate 也可用作疟疾的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Quinidine hydrochloride monohydrate 和 Quinidine (15% dihydroquinidine) 通常具有更好的水溶性和稳定性。

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Quinidine polygalacturonate Chemical Structure

Quinidine polygalacturonate Chemical Structure

CAS No. : 27555-34-6

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Quinidine polygalacturonate 的其他形式现货产品:

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Other Forms of Quinidine polygalacturonate:

Quinidine polygalacturonate 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

Quinidine polygalacturonate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinidine polygalacturonate 相关抗体:

Apoptosis Analysis[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.

Cell Cytotoxicity Assay[4]

Cell Line: MES-SA and MESSA/DX5 cells
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.
体内研究
(In Vivo)

Quinidine polygalacturonate shows effects on the PTZ-induced seizure threshold[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage: 10, 20, and 30 mg/kg
Administration: Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result: Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Formula

C26H34N2O9
CAS 号
中文名称

奎尼丁聚半乳糖酸酯；异奎宁聚半乳糖酸酯；奎尼定聚半乳糖酸酯；喹啉丁聚半乳糖酸酯；奎纳定聚半乳糖酸酯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Quinidine polygalacturonate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinidine polygalacturonate27555-34-6奎尼丁聚半乳糖酸酯异奎宁聚半乳糖酸酯奎尼定聚半乳糖酸酯喹啉丁聚半乳糖酸酯奎纳定聚半乳糖酸酯Potassium ChannelCytochrome P450ApoptosisParasiteKcsACYPsoral activitymalariaMES-SAMESSA/DX5Inhibitorinhibitorinhibit

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