2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Anti-infection
  3. Histamine Receptor SARS-CoV Bacterial
  4. Ranitidine bismuth citrate

Ranitidine bismuth citrate  (Synonyms: 枸椽酸铋雷尼替丁)

目录号: HY-B0693A
产品使用指南 技术支持

Ranitidine 是一种强效、选择性、具有口服活性的组胺 H2 受体 (histamine H2-receptor) 拮抗剂，可抑制胃液分泌。Ranitidine 可拮抗 Histamine (HY-B1204) 诱导的豚鼠离体大鼠心房扩张和组胺诱导的大鼠离体子宫角松弛，pA2 值分别为 7.2 和 6.95。Ranitidine 对 SARS-CoV-2 感染细胞具有选择性。Ranitidine 还具有抗幽门螺杆菌感染的作用。Ranitidine 可抑制小鼠乳腺肿瘤的发展和扩散。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ranitidine bismuth citrate Chemical Structure

Ranitidine bismuth citrate Chemical Structure

CAS No. : 128345-62-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Ranitidine bismuth citrate 的其他形式现货产品:

Customer Review

Other Forms of Ranitidine bismuth citrate:

Ranitidine bismuth citrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ranitidine bismuth citrate is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine bismuth citrate antagonizes Histamine (HY-B1204)-induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine bismuth citrate has selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate also has anti-Helicobacter pylori infection. Ranitidine bismuth citrate inhibits breast tumor development and spread in mice[1][2][3][4].

IC50 & Target

H2 Receptor

 

体外研究
(In Vitro)

Ranitidine bismuth citrate (0.1-1 μM，5 分钟) 是 SARS-CoV-2 解旋酶的 ATPase (IC50 = 0.69 μM，Ki = 0.97 μM) 和 DNA 解旋 (IC50 = 0.74 μM，Ki = 0.39 μM) 的强效不可逆抑制剂[2]。
Ranitidine bismuth citrate (24 小时) 对 SARS-CoV-2 表现出强效活性，在 Vero E6 细胞中的 EC50 值为 2.3 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ranitidine bismuth citrate 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: Monkey kidney Vero E6 cells, human colorectal Caco-2 cells
Concentration: 400-3,740 μM
Incubation Time: 48 hours
Result: Showed low cytotoxicity with the 50% cytotoxicity concentrations (CC50) ranging from 2.2 mM and 2.5 mM.
体内研究
(In Vivo)

Ranitidine (0.03-3 mg/kg；静脉注射；一次) bismuth citrate 可抑制麻醉大鼠灌注胃制剂中 Histamine (HY-B1204) 和 Pentagastrin (HY-A0261) 诱导的胃酸分泌[1]。
Ranitidine bismuth citrate (150 mg/kg；腹腔注射；每日一次；4 天) 可抑制 SARS-CoV-2 复制，并缓解金黄叙利亚仓鼠模型中的病毒相关肺炎[2]。
在大鼠实验中，Ranitidine bismuth citrate (3-30 mg/kg，口服) 可预防乙醇引起的胃底损伤 (胃底损伤) 和吲哚美辛引起的胃窦损伤 (胃窦损伤)[3]。
在自然寄生有鼬形水蚤 (H. mustelae) 的雪貂中，Ranitidine bismuth citrate (口服；12-24 mg/kg；每日两次；持续4周) 可导致剂量相关的鼬形水蚤 (H. mustelae) 清除率[3]。
Ranitidine (8 mg/kg；口服；每隔一天给药；给药 8 天) bismuth citrate 在 BALB/c 小鼠的脾脏和骨髓中，使 CD11b+Ly6Chi细胞数量减少[4]。
Ranitidine (8 mg/kg；口服；每隔一天给药；给药 8 天) bismuth citrate 在荷 4T1 乳腺癌的 BALB/c 小鼠中，抑制了肺转移[4]。
Ranitidine (8 mg/kg；口服；每隔一天给药；给药 14 天) bismuth citrate 在 C57BL/6 小鼠的 E0771 乳腺癌模型中，抑制了原发性肿瘤生长[4]。
Ranitidine (剂量使小鼠每天摄入 6-8 mg/kg；加入饮用水；每 3 天更换一次；从断奶开始 (约 4 周) 至实验结束 (23-26 周)) bismuth citrate 在 LKB1-/-NIC 小鼠中，增加了乳腺肿瘤发生的潜伏期并减少了肿瘤数量[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats (100 to 120 g) were anaesthetized with sodium pentobarbitone (50 mg/kg i.p.), and intravenous with Histamine (100 μg/kg/min) or Pentagastrin (1 μg/kg/min)[1].
Dosage: 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 0.6 mg/kg, 1 mg/kg, 3 mg/kg
Administration: i.v.; once
Result: Inhibited Histamine- and Pentagastrin-induced gastric acid secretion in the perfused stomach preparation of the anaesthetized rat.
Animal Model: Male and female Syrian hamsters (6-10 weeks)[2]
Dosage: 150 mg/kg
Administration: Intraperitoneally given; once daily; 4 days
Result: Suppressed SARS-CoV-2 replication, and relieved virus-associated pneumonia in a golden Syrian hamster model.
Animal Model: BALB/c female mice (5-6-8 week old), orthotopic breast cancer model by injecting 100,000 4T1 cells subcutaneously into the mammary fat pad near the fourth nipple[4].
Dosage: 8 mg/kg
Administration: Oral administration, every other day, 8 days
Result: Decreased the proportion of CD11b+Ly6Chi monocytic cells in the spleen and inhibited lung metastasis.
Animal Model: C57BL/6 female mice (6-8 week old), orthotopic breast cancer model by injecting 200,000 E0771 cells in 100 μL of Matrigel subcutaneously into the mammary fat pad near the fourth nipple[4].
Dosage: 8 mg/kg
Administration: Oral administration, every other day, 8 days
Result: Decreased primary tumor growth starting from approximately day 13 post-tumor cell injection.
Animal Model: LKB1-/-/NIC female mice (weaned at about 4 weeks old), spontaneous tumor development model starting from weaning[4].
Dosage: 6-8 mg/kg
Administration: Oral administration, every 3 days, from weaning until the end of the experiment
Result: Increased the latency of tumorigenesis by an additional 24 days and reduced the average number of tumors per mouse.
分子量

712.48

Formula

C19H27BiN4O10S
CAS 号
中文名称

枸椽酸铋雷尼替丁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ranitidine bismuth citrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ranitidine bismuth128345-62-0枸椽酸铋雷尼替丁Histamine ReceptorSARS-CoVBacterialSARS coronavirusranitidine bismuth citrateRBCorally activeHelicobacter PyloriHelicobacter mustelaeSARS-CoV-2histamine H2Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ranitidine bismuth citrate
目录号：
HY-B0693A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z