Coagulation factor VII/F7 蛋白, Human (His-SUMO)

Coagulation factor VII (F7) initiates the extrinsic pathway of blood coagulation. As a circulating zymogen, F7 is activated to F7a through proteolysis induced by factor Xa, factor XIIa, factor IXa, or thrombin. In the presence of tissue factor and calcium ions, F7a catalyzes limited proteolysis of factor X, converting it to factor Xa. F7a can also convert factor IX to factor IXa, emphasizing its pivotal role in coagulation cascades. Coagulation factor VII/F7 Protein, Human (His-SUMO) is the recombinant human-derived Coagulation factor VII/F7 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of Coagulation factor VII/F7 Protein, Human (His-SUMO) is 152 a.a., with molecular weight of 33 kDa.

凝血因子 VII (F7) 在启动外源性凝血途径中发挥着至关重要的作用。作为一种以其酶原形式在血液中循环的丝氨酸蛋白酶，因子 VII 通过因子 Xa、因子 XIIa、因子 IXa 或凝血酶诱导的轻微蛋白水解而活化为因子 VIIa。在组织因子和钙离子存在的情况下，因子 VIIa 进一步催化因子 X 的有限蛋白水解，将其转化为因子 Xa。此外，在存在组织因子和钙的情况下，因子 VIIa 能够将因子 IX 转化为因子 IXa，突出了其在复杂的凝血过程级联中的关键功能。

Human

E. coli

N-SUMO;N-6*His

P08709 (A61-R212)

2155  [NCBI]

ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGR

33 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.