1. Metabolic Enzyme/Protease
  2. Thrombin

Thrombin

Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology. Considering the clinical development of selective anticoagulants including direct thrombin inhibitors.

Thrombin 相关产品 (20):

Cat. No. Product Name Effect Purity
  • HY-12821
    AEBSF hydrochloride Inhibitor 99.44%
    AEBSF hydrochloride 是丝氨酸蛋白酶 的不可逆抑制剂,可抑制例如胰凝乳蛋白酶,激肽释放酶,纤溶酶,凝血酶和胰蛋白酶。
  • HY-10163
    Dabigatran Inhibitor
    Dabigatran(BIB-953; BIBR 953ZW)是可逆的高活性直接凝血酶抑制剂(DTI),Ki为4.5 nM。
  • HY-15664
    Bivalirudin Trifluoroacetate Inhibitor 99.76%
    Bivalirudin 三氟醋酸盐是是20个氨基多肽,可逆地抑制凝血酶。
  • HY-10274
    Dabigatran etexilate Inhibitor 99.37%
    Dabigatran etexilate(BIBR-1048)是口服活性的dabigatran原药,是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
  • HY-114164
    Thrombin
    Thrombin 是一种胰蛋白酶样别构丝氨酸蛋白酶,在凝血连锁反应中起作用。
  • HY-B0375A
    Argatroban monohydrate Inhibitor 99.95%
    Argatroban (monohydrate) (MD-805 (monohydrate)) 是 thrombin 选择性抑制剂。
  • HY-10274A
    Dabigatran etexilate mesylate Inhibitor 99.60%
    Dabigatran etexilate mesylate (BIBR 1048MS)是口服活性的dabigatran前药。Dabigatran是可逆的直接凝血酶抑制剂(DTI),Ki为4.5 nM。
  • HY-17378
    Dabigatran ethyl ester Inhibitor 99.26%
    Dabigatran (ethyl ester)是新型的口服抗凝化合物和凝血酶抑制剂。
  • HY-B0209
    Metolazone Inhibitor 99.32%
    Metolazone(Zaroxolyn)可抗心力衰竭和高血压。
  • HY-77521
    Dabigatran ethyl ester hydrochloride Inhibitor 99.36%
    Dabigatran ethyl ester hydrochloride是有效地核糖基二氢烟酰胺脱氢酶(NQO2)抑制剂,IC50值为0.8 μM。也是凝血酶的抑制剂。
  • HY-101054
    NQ301 98.74%
    NQ301是一种抗血栓剂; 可抑制胶原蛋白激发的兔血小板聚集,IC50值为10 mg/mL。
  • HY-B0375
    Argatroban Inhibitor
    Argatroban (MD-805) 是凝血酶选择性抑制剂。
  • HY-10163AS
    Dabigatran D4 hydrochloride Inhibitor
    Dabigatran D4盐酸盐是Dabigatran氘代化合物标准品。
  • HY-15759A
    Napsagatran hydrate Inhibitor
    Napsagatran hydrate 是一种新型的特异性凝血酶 (thrombin) 抑制剂。
  • HY-19373
    RWJ-445167 Inhibitor
    RWJ-445167 是一种有效的 thrombinfactor Xa 双重抑制剂,Ki 值分别为 4.0 nM 和 230 nM,具有抗血栓形成的作用。
  • HY-19660
    Inogatran Inhibitor
    Inogatran 是一种合成的 thrombin 抑制剂,主要用于预防动脉和静脉血栓性疾病。
  • HY-P1000
    Sfllrnpndkyepf Agonist 98.22%
    SFLLRNPNDKYEPF是人工合成的thrombin受体激动剂肽段。
  • HY-100245
    OM-189 Inhibitor
    OM-189 是一种人工合成且有选择性的凝血酶抑制剂。
  • HY-U00370
    Thrombin inhibitor 1 Inhibitor
    Thrombin inhibitor 1 是一种有效的凝血酶抑制剂 (Ki=0.66 nM,2xaPTT=0.43 μM)。
  • HY-U00039
    Desethyl KBT-3022
    Desethyl KBT-3022是新型抗血小板药物KBT-3022的主要活性代谢物。
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