1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. DC-SIGN1/CD209 DC-SIGN1/CD209
  5. DC-SIGN/CD209 蛋白, Human (HEK293, His)

DC-SIGN/CD209 蛋白, Human (HEK293, His)

目录号: HY-P704561
产品使用指南 技术支持

DC-SIGN/CD209 蛋白在未成熟树突状细胞 (DC) 上表达,是启动初级免疫反应的重要病原体识别受体。它介导溶酶体室内病原体的内吞作用和随后的降解。DC-SIGN/CD209 蛋白, Human (HEK293, His) 是重组的 DC-SIGN/CD209 蛋白,由 HEK293 表达,带有 N-His 标签。

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SPR 检测服务   重组蛋白定制服务

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描述

The DC-SIGN/CD209 protein is expressed on immature dendritic cells (DC) and is an important pathogen recognition receptor that initiates primary immune responses. It mediates endocytosis and subsequent degradation of pathogens within the lysosomal compartment. DC-SIGN/CD209 Protein, Human (HEK293, His) is the recombinant human-derived DC-SIGN/CD209 protein, expressed by HEK293, with N-His labeled tag.

研究背景

DC-SIGN/CD209 蛋白表达于未成熟树突状细胞 (DC) 表面,是关键的病原体识别受体,在启动初级免疫反应中发挥着至关重要的作用。该受体参与病原体的内吞作用,导致其随后在溶酶体室内降解。在此过程之后,DC-SIGN 返回细胞膜表面,通过 MHC II 类蛋白将病原体衍生的抗原呈递给静息 T 细胞,从而触发适应性免疫反应。在 DC 上,它充当 ICAM2 和 ICAM3 的高亲和力受体,与甘露糖样碳水化合物结合。值得注意的是,DC-SIGN 可能充当 DC 滚动受体,通过与内皮 ICAM2 相互作用,促进 DC 前体从血流跨内皮迁移到组织。此外,它似乎通过与 DC 和 T 细胞之间形成的免疫突触内 T 细胞上的 ICAM3 结合来调节 DC 诱导的 T 细胞增殖。

种属

Human

表达系统

HEK293

标签

N-His

蛋白编号

Q9NNX6-1 (Q59-A404)

基因 ID

30835

蛋白结构
N-term
His
CD209 (Q59-A404)
Accession # Q9NNX6-1
C-term
同用名
rHuCD209 antigen/CD209, Fc; CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; DCSIGN; DC-SIGN; DC-SIGN1; CD209 Antigen
预测分子量
41.3 kDa
分子量

Approximately 40-50 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
DC-SIGN/CD209 Protein, Human (HEK293, His)
目录号:
HY-P704561
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