Endothelin-1/Edn1 蛋白, Rat (His-KSI)

Endothelin-1/Edn1 protein is an endothelium-derived vasoconstrictor peptide that plays a crucial role in vascular regulation. As a possible ligand of the G protein-coupled receptors EDNRA and EDNRB, it initiates a signaling cascade involving PTK2B, BCAR1, BCAR3 and the GTPases RAP1 and RHOA in glomerular mesangial cells, helping to regulate vascular tone. Endothelin-1/Edn1 Protein, Rat (His-KSI) is the recombinant rat-derived Endothelin-1/Edn1 protein, expressed by E. coli , with N-6*His, N-KSI labeled tag. The total length of Endothelin-1/Edn1 Protein, Rat (His-KSI) is 21 a.a., with molecular weight of ~17.8 kDa.

Endothelin-1 (Edn1) 是一种源自内皮细胞的血管收缩肽，通过 G 蛋白偶联受体 EDNRA 和 EDNRB 发挥作用。它可能作为这些受体的配体，激活肾小球系膜细胞中涉及 PTK2B、BCAR1、BCAR3 以及 GTPases RAP1 和 RHOA 的下游信号级联。此外，Endothelin-1 与 DEAR/FBXW7-AS1 受体结合。这种复杂的相互作用凸显了其在介导各种细胞反应中的作用，特别是在调节血管张力和系膜细胞功能中。Endothelin-1 的多方面作用强调了其在血管生理学中的重要性，并表明其参与多种细胞过程（参考：提供的信息）。

Rat

E. coli

N-6*His;N-KSI

P22388 (53C-73W)

24323  [NCBI]

CSCSSLMDKECVYFCHLDIIW

Approximately 17.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.