FGFR-4 蛋白, Human (Biotinylated, HEK293, His)

The FGFR-4 protein is a tyrosine protein kinase and cell surface receptor for fibroblast growth factor that regulates diverse cellular processes such as proliferation, differentiation, migration, lipid metabolism, and bile acid biosynthesis. Notably, it contributes to the downregulation of the bile acid synthase CYP7A1 in response to FGF19. FGFR-4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived FGFR-4 protein, expressed by HEK293 , with C-His labeled tag. The total length of FGFR-4 Protein, Human (Biotinylated, HEK293, His) is 369 a.a., with molecular weight of ~60.8 kDa.

FGFR-4 蛋白是一种酪氨酸蛋白激酶，充当成纤维细胞生长因子的细胞表面受体。它在调节细胞增殖、分化、迁移、脂质代谢、胆汁酸生物合成、葡萄糖摄取、维生素 D 代谢和磷酸盐稳态中发挥着至关重要的作用。其重要功能之一是响应 FGF19，促进胆汁酸合成关键酶 CYP7A1 的下调。配体结合后，FGFR-4 磷酸化 PLCG1 和 FRS2，导致各种信号级联的激活。这种激活导致二酰基甘油和肌醇 1,4,5-三磷酸的产生，它们是重要的细胞信号分子。此外，FRS2 的磷酸化会触发 GRB2、GAB1、PIK3R1 和 SOS1 的募集，从而激活 RAS、MAPK1/ERK2、MAPK3/ERK1 和 AKT1 信号通路。FGFR-4 还促进基质蛋白酶 MMP14 的 SRC 依赖性磷酸化，并促进其溶酶体降解。FGFR-4 的信号传导通过受体内化和降解受到严格调节，MMP14 在此过程中提供帮助。然而，导致组成型激酶激活或损害正常 FGFR-4 失活的突变可能导致信号传导异常。

Human

HEK293

C-His

P22455 (M1-D369)

2264  [NCBI]

Approximately 60.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.