2. 重组蛋白
  3. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators Fluorescent-labeled Recombinant Proteins
  4. VEGF & VEGFR Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. VEGFR
  6. FLK-1/VEGFR-2 FLK-1/VEGFR-2
  7. FITC-Labeled VEGFR-2 蛋白, Human (HEK293, His)

FITC-Labeled VEGFR-2 蛋白, Human (HEK293, His)

目录号: HY-P701264
产品使用指南

VEGFR-2 是 VEGFA, VEGFC 和 VEGFD 的细胞表面受体的酪氨酸蛋白激酶，可介导 MAPK1/ERK2、MAPK3/ERK1 和 MAP 激酶信号通路以及 AKT1 信号通路的激活。VEGFR-2可促进内皮细胞的增殖、存活、迁移和分化。VEGFR-2 的过表达与肿瘤的发生发展有关。FITC-Labeled VEGFR-2 蛋白, Human (HEK293, His) 是重组的 FITC 标记的 VEGFR-2 蛋白，由 HEK293 表达，带有 His 标签。FITC-Labeled VEGFR-2 蛋白, Human (HEK293, His) 全长 745 个氨基酸，分子量为 110-120 kDa。

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描述

VEGFR-2 is a tyrosine-protein kinase of the cell surface receptors of VEGFA, VEGFC, and VEGFD that mediates activation of the MAPK1/ERK2, MAPK3/ERK1, and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. VEGFR-2 can promote the proliferation, survival, migration and differentiation of endothelial cells. Overexpression of VEGFR-2 is associated with the development of tumors. FITC-Labeled VEGFR-2 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled VEGFR-2 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled VEGFR-2 Protein, Human (HEK293, His) is 745 a.a., with molecular weight of 110-120 kDa.
研究背景

VEGF 受体 (VEGFRs) 是血管内皮生长因子 (VEGF) 的受体，主要有三种亚型，VEGFR-1,、VEGFR-2 和VEGFR-3。VEGFR-2 可作为 VEGFA, VEGFC 和 VEGFD 的细胞表面受体的酪氨酸蛋白激酶，在血管生成、血管发育、血管通透性和胚胎造血中起重要作用。可促进内皮细胞的增殖、存活、迁移和分化。促进肌动蛋白细胞骨架的重组。VEGFR-2 通过形成异源二聚体调节VEGFR-1 (FLT1) 和 VEGFR-3 (FLT40) 信号。VEGFR-2 可介导 MAPK1/ERK2、MAPK3/ERK1 和 MAP 激酶信号通路以及 AKT1 信号通路的激活。介导磷脂酰肌醇 3-激酶调控亚基 PIK3R1 的磷酸化、肌动蛋白细胞骨架的重组和 PTK2/FAK1 的激活。VEGFA 介导的 NOS2 和 NOS3 的诱导是必需的，导致内皮细胞产生信号分子一氧化氮 (NO)。磷酸化 PLCG1 。促进 FYN、NCK1、NOS3、PIK3R1、PTK2/FAK1 和 SRC 的磷酸化。VEGFR-2 的过表达与肿瘤的发生有关。
种属

Human
表达系统

HEK293
标签

His
蛋白编号

AAI31823.1 (A20-E764)
基因 ID

3791
同用名
KDR; CD309; FLK1; VEGFR; VEGFR2
分子量

110-120 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FITC-Labeled VEGFR-2 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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