GAD2/GAD65 蛋白, Human (sf9, GST)

GAD2/GAD65 proteins are key enzymes in neurotransmitter metabolism, specifically catalyzing the production of gamma-aminobutyric acid (GABA). GABA is an important inhibitory neurotransmitter in the central nervous system, playing a key role in regulating neuronal excitability and maintaining the balance between excitation and inhibition in the brain. GAD2/GAD65 Protein, Human (sf9, GST) is the recombinant human-derived GAD2/GAD65 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of GAD2/GAD65 Protein, Human (sf9, GST) is 585 a.a., with molecular weight of ~92.6 kDa.

GAD2，也称为 GAD65（谷氨酸脱羧酶 2），是一种酶，通过催化谷氨酸转化为 γ-氨基丁酸 (GABA)，在神经递质调节中发挥着至关重要的作用。GAD2/GAD65 是谷氨酸脱羧酶的主要亚型，其酶活性对于维持中枢神经系统兴奋性和抑制性神经传递之间的平衡至关重要。GABA 是主要的抑制性神经递质，由 GAD2/GAD65 合成，有助于调节神经元兴奋性。GAD2 活性失调与多种神经系统疾病有关，强调了这种酶在神经功能中的重要性，并强调了其作为治疗靶点的潜力。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

Sf9 insect cells

N-GST

Q05329 (M1-L585)

2572  [NCBI]

Approximately 92.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 200 mM Tris, 150mM NaCl, 10% Glycerol, 1mM GSH, pH8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.