GPIHBP1 蛋白, Human (HEK293, Fc)

The GPIHBP1 protein mediates lipid metabolism by transporting lipoprotein lipase LPL, anchoring it in capillaries, and preventing loss of activity. It has a crucial role in chylomicron lipolysis, triglyceride metabolism, and overall lipid homeostasis. GPIHBP1 Protein, Human (HEK293, Fc) is the recombinant human-derived GPIHBP1 protein, expressed by HEK293 , with C-hFc labeled tag.

GPIHBP1 蛋白通过促进脂蛋白脂肪酶 LPL 从毛细血管内皮细胞的基底外侧转运至顶面并将 LPL 锚定在毛细血管腔内的内皮细胞表面上，充当脂质代谢的关键介质。通过这种能力，GPIHBP1 可以保护 LPL 免遭活性丧失和 ANGPTL4 介导的解折叠，在 LPL 乳糜微粒的脂肪分解过程、甘油三酯代谢和整体脂质稳态中发挥关键作用。该蛋白具有结合乳糜微粒和含有 APOA5 的磷脂颗粒的能力，有助于其在脂蛋白相互作用中的作用。此外，GPIHBP1 与高密度脂蛋白 (HDL) 结合，表明在从 HDL 摄取脂质中发挥作用。该蛋白质主要表现出单体状态，但也可以形成同二聚体和同寡聚体。它与 LPL 的相互作用以 1:1 的化学计量发生，强调了它参与脂质加工的精确性。GPIHBP1 复杂的相互作用网络，包括与 HDL 和 APOA5 的相互作用网络，强调了其在血管系统内协调脂质运输和维持脂质稳态方面的重要性。

Human

HEK293

C-hFc

Q8IV16 (T22-G151)

338328  [NCBI]

Partial

TQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSRVLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPWQSSRVQDPTG

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.