2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. GSTP1 蛋白, Cricetulus longicaudatus (Baculovirus, His-Myc)

GSTP1 蛋白, Cricetulus longicaudatus (Baculovirus, His-Myc)

目录号: HY-P72050
产品使用指南

GSTP1 是一种关键蛋白，通过将还原型谷胱甘肽与疏水性亲电子试剂结合来帮助细胞解毒。它还形成 PGA2 和 PGJ2 的谷胱甘肽缀合物，并有助于赫泊西林的合成。此外，GSTP1 调节 CDK5 活性，防止神经退行性变。这种多功能酶可维护细胞稳态，并在各种生化途径中发挥至关重要的作用。GSTP1 蛋白, Cricetulus longicaudatus (Baculovirus, His-Myc) 是重组的 GSTP1 蛋白，由 Sf9 insect cells 表达，带有 N-10*His, C-Myc 标签。GSTP1 蛋白, Cricetulus longicaudatus (Baculovirus, His-Myc) 全长 210 个氨基酸，分子量约为 ~27.5 kDa。

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描述

GSTP1, a key protein, aids in cellular detoxification by conjugating reduced glutathione to hydrophobic electrophiles. It also forms glutathione conjugates for PGA2 and PGJ2 and contributes to hepoxilin synthesis. Additionally, GSTP1 regulates CDK5 activity, preventing neurodegeneration. This versatile enzyme safeguards cellular homeostasis and plays a crucial role in various biochemical pathways. GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) is the recombinant GSTP1 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) is 210 a.a., with molecular weight of ~27.5 kDa.
研究背景

GSTP1 是细胞解毒过程中的关键参与者，有助于还原型谷胱甘肽与多种外源和内源的疏水性亲电子试剂的结合。这种酶活性延伸至前列腺素 A2 (PGA2) 和前列腺素 J2 (PGJ2) 谷胱甘肽缀合物的形成，并有助于独特的赫泊西林区域异构体的合成。除了在异生素代谢中的作用外，GSTP1 还通过负向调节 CDK5 活性来发挥调节功能，通过阻止 p25/p35 易位到 CDK5 来防止神经变性。这种多方面的酶是细胞稳态的关键守护者，参与多种生化途径，对细胞健康和对各种生理挑战的反应具有影响。
种属

Others
表达系统

Sf9 insect cells
标签

N-10*His;C-Myc
蛋白编号

P46424 (M1-Q210)
基因 ID

100689311  [NCBI]
蛋白结构
N-term
10*His
GSTP1 (M1-Q210)
Accession # P46424
Myc
C-term
同用名
GSTP1Glutathione S-transferase P; EC 2.5.1.18; GST class-pi
氨基酸序列

MPPYTIVYFPVRGRCEAMRILLADQGQSWKEEVVTVETWRKGSLKSTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKDQREAALVDMVNDGVEDLRCKYITLIYTKYEEGKDDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFVDYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPDHVNRPINGNGKQ

分子量

Approximately 27.5 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GSTP1 Protein, Cricetulus longicaudatus (Baculovirus, His-Myc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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