1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins
  4. ICOS/CD278 ICOS/CD278
  5. ICOS 蛋白, Rat (C137S, C138S, HEK293, His)

ICOS 蛋白, Rat (C137S, C138S, HEK293, His)

目录号: HY-P704668
产品使用指南 技术支持

ICOS是T细胞功能的关键蛋白,可以显着增强各种T细胞对外来抗原的反应。它在促进T细胞增殖、淋巴因子分泌和细胞间相互作用分子上调、促进B细胞抗体高效分泌等方面发挥着至关重要的作用。ICOS 蛋白, Rat (C137S, C138S, HEK293, His) 是重组的 ICOS 蛋白,由 HEK293 表达,带有 C-His 标签。

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规格 是否有货
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描述

ICOS is a key protein for T cell function and can significantly enhance various T cell responses to foreign antigens. It plays a crucial role in promoting T cell proliferation, lymphokine secretion and upregulation of intercellular interaction molecules, and promoting efficient secretion of B cell antibodies. ICOS Protein, Rat (C137S, C138S, HEK293, His) is the recombinant rat-derived ICOS protein, expressed by HEK293, with C-His labeled tag.

研究背景

ICOS 是 T 细胞功能中必需的蛋白质,可显着增强 T 细胞对外来抗原的各种反应。它在促进T细胞增殖、分泌淋巴因子、上调细胞间相互作用分子以及有效协助B细胞抗体分泌等方面发挥着关键作用。值得注意的是,ICOS 对于 T 细胞依赖性抗原的正常抗体反应是不可或缺的,可促进 T 细胞和 B 细胞之间的相互作用。有趣的是,ICOS 不会提高白细胞介素 2 的产生,但会促进白细胞介素 10 的合成。此外,它在防止预激活 T 细胞凋亡方面发挥着至关重要的作用,并在 CD40 介导的免疫球蛋白同种型类型转换中发挥重要作用。该蛋白质通过二硫键形成同二聚体,在调节免疫反应中发挥多方面的作用。

种属

Rat

表达系统

HEK293

标签

C-His

蛋白编号

Q9R1T7-1 (E21-P145, C137S, C138S)

基因 ID

64545

蛋白结构
N-term
ICOS (E21-P145, C137S, C138S)
Accession # Q9R1T7-1
His
C-term
同用名
Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS
预测分子量
15.9 kDa.
分子量

Approximately 24-26 kDa and 60-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ICOS Protein, Rat (C137S, C138S, HEK293, His)
目录号:
HY-P704668
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