1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-17
  5. IL-17F
  6. IL-17F 蛋白, Human (H161R, HEK293, His)

IL-17F 蛋白, Human (H161R, HEK293, His)

目录号: HY-P78669
产品使用指南 技术支持

IL-17F 蛋白是先天性和适应性免疫中的关键效应细胞因子,可维持组织完整性并抵御微生物。它通过 IL17RA-IL17RC 受体复合物发挥作用,激活 NF-kappa-B 和 MAPkinase 通路,并诱导免疫相关基因的转录。IL-17F 蛋白, Human (H161R, HEK293, His) 是重组的 IL-17F 蛋白,由 HEK293 表达,带有 N-His 标签。 和 H161R,,, 突变。IL-17F 蛋白, Human (H161R, HEK293, His) 全长 133 个氨基酸,分子量约为 ~23 kDa。

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     可免费申领三个不同产品的试用装。

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描述

IL-17F protein is a key effector cytokine in innate and adaptive immunity that maintains tissue integrity and protects against microorganisms. It acts through the IL17RA-IL17RC receptor complex, activates the NF-kappa-B and MAPkinase pathways, and induces the transcription of immune-related genes. IL-17F Protein, Human (H161R, HEK293, His) is the recombinant human-derived IL-17F protein, expressed by HEK293 , with N-His labeled tag and H161R, , , , mutation. The total length of IL-17F Protein, Human (H161R, HEK293, His) is 133 a.a., with molecular weight of ~23 kDa.

研究背景

IL-17F 蛋白是先天性和适应性免疫系统中的关键效应细胞因子,对于抗菌防御和组织完整性维护至关重要。它通过 IL17RA-IL17RC 受体复合物发挥作用,触发下游 NF-kappa-B 和 MAPkinase 通路的激活,从而导致各种免疫相关基因的转录激活。IL-17F 主要与 Th17 细胞相关,诱导中性粒细胞活化、抗菌肽产生并调节免疫耐受。它与 IL-17A 形成同二聚体和异二聚体,影响从交感神经支配到微生物群调节的多种生物过程。IL-17F 协调的复杂相互作用和信号通路强调了其在免疫反应和细胞稳态中的多方面作用。

种属

Human

表达系统

HEK293

标签

N-His

蛋白编号

Q96PD4 (R31-Q163, H161R)

基因 ID
蛋白结构
N-term
His
IL-17F (R31-Q163, H161R)
Accession # Q96PD4
C-term
中文名
白介素-17F 蛋白
同用名
IL-17F; Interleukin-17F; Cytokine ML-1
分子量

Approximately 23 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

IL-17F Protein, Human (H161R, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-17F Protein, Human (H161R, HEK293, His)
目录号:
HY-P78669
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