2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-33
  6. IL-33 蛋白, Human (C208S, C227S, C232S, C259S, HEK293, His )

IL-33 蛋白, Human (C208S, C227S, C232S, C259S, HEK293, His )

目录号: HY-P704714
产品使用指南 技术支持

IL-33 蛋白作为细胞因子，与 IL1RL1/ST2 受体结合并通过其发出信号，从而激活靶细胞中的 NF-kappa-B 和 MAPK 信号通路。它参与 Th2 细胞的成熟，并有助于 T 辅助细胞 2 型相关细胞因子的分泌。IL-33 蛋白, Human (C208S, C227S, C232S, C259S, HEK293, His ) 是重组的 IL-33 蛋白，由 HEK293 表达，带有 C-His 标签。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

IL-33 protein, as a cytokine, binds to and signals through the IL1RL1/ST2 receptor, thereby activating the NF-kappa-B and MAPK signaling pathways in target cells. It is involved in the maturation of Th2 cells and contributes to the secretion of T helper cell type 2 related cytokines. IL-33 Protein, Human (C208S, C227S, C232S, C259S, HEK293, His ) is the recombinant human-derived IL-33 protein, expressed by HEK293, with C-His labeled tag.
研究背景

IL-33 蛋白作为细胞因子，与 IL1RL1/ST2 受体结合并通过其发出信号，从而激活靶细胞中的 NF-kappa-B 和 MAPK 信号通路。它参与 Th2 细胞的成熟，有助于分泌 T 辅助细胞 2 型相关细胞因子。此外，IL-33 在肥大细胞、嗜碱性粒细胞、嗜酸性粒细胞和自然杀伤细胞的激活中发挥着至关重要的作用。它作为交替激活的巨噬细胞极化的增强剂，作为 Th2 细胞的化学引诱剂，并可能起到“警报器”的作用，在组织损伤期间放大免疫反应。IL-33 可诱导 UCP2 依赖性线粒体快速重新布线，减少活性氧的产生并保持克雷布斯循环的完整性，这对于衣康酸的持续产生以及随后的 GATA3 依赖性炎症消退分化至关重要激活巨噬细胞。在静止内皮细胞中，未切割形式的 IL-33 组成型且大量表达，作为具有转录抑制特性的染色质相关核因子，可能隔离核 NF-kappaB/RELA，从而降低其靶标的表达；这种形式在血管生成或促炎症激活后迅速消失。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

O95760-1 (H109-T270, C208S, C227S, C232S, C259S)
基因 ID

90865
蛋白结构
N-term
IL-33 (H109-T270,C208S, C227S, C232S, C259S)
Accession # O95760-1
His
C-term
同用名
rHuIL-33; IL-1F11; NF-HEV; DVS 27
预测分子量
20.2 kDa.
分子量

Approximately 25-30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
糖基化修饰
Yes
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

IL-33 Protein, Human (C208S, C227S, C232S, C259S, HEK293, His ) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
IL-33 Protein, Human (C208S, C227S, C232S, C259S, HEK293, His )
目录号：
HY-P704714
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z