1. 重组蛋白
  2. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens
  3. TNF Superfamily Stimulatory Immune Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins
  4. TNF Superfamily Ligands OX40 Ligand OX40 Ligand
  5. OX40 Ligand
  6. OX40 Ligand/TNFSF4 蛋白, Human (HEK293, mFc)

OX40 Ligand/TNFSF4 蛋白, Human (HEK293, mFc)

目录号: HY-P704291
产品使用指南 技术支持

OX40 配体/TNFSF4 蛋白是一种细胞因子,与 TNFRSF4 特异性结合,作为有效的 T 细胞共刺激剂,促进增殖和细胞因子的产生。作为同源三聚体,它的参与通过激活和扩增 T 细胞来增强免疫反应。与 TNFRSF4 的相互作用有助于复杂的调节,这对于调节 T 细胞功能和实现有效且受控的免疫激活至关重要。OX40 Ligand/TNFSF4 蛋白, Human (HEK293, mFc) 是重组的 OX40 Ligand/TNFSF4 蛋白,由 HEK293 表达,带有 C-mFc 标签。

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描述

OX40 Ligand/TNFSF4 Protein, a cytokine, binds specifically to TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. Operating as a homotrimer, its engagement enhances immune response by activating and expanding T-cells. The interaction with TNFRSF4 contributes to intricate regulation, crucial for modulating T-cell functions and achieving effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Human (HEK293, mFc) is the recombinant human-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293, with C-mFc labeled tag.

研究背景

OX40 配体/TNFSF4 蛋白是一种细胞因子,可特异性结合 TNFRSF4,并作为 T 细胞增殖和细胞因子产生的有效共刺激剂。作为同源三聚体,它与 TNFRSF4 结合,通过促进 T 细胞的激活和扩增来增强免疫反应。OX40 配体与其受体 TNFRSF4 之间的相互作用有助于 T 细胞介导的免疫反应的复杂调节,在调节 T 细胞功能以实现有效且受控的免疫激活方面发挥着至关重要的作用。

种属

Human

表达系统

HEK293

标签

C-mFc

蛋白编号

P23510-1 (Q51-L183)

基因 ID

7292

蛋白结构
N-term
OX40L (Q51-L183)
Accession # P23510
mFc
C-term
蛋白长度

Extracellular Domain

同用名
OX40L; OX-40L; OX4OL; CD252; TNFSF4; OX40 Ligand; CD134 ligand; CD134L;  TXGP1; Glycoprotein Gp34
预测分子量
42.3 kDa
分子量

Approximately 53-60 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

糖基化修饰
Yes
纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
OX40 Ligand/TNFSF4 Protein, Human (HEK293, mFc)
目录号:
HY-P704291
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