2. 重组蛋白
  3. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens
  4. TNF Superfamily Stimulatory Immune Checkpoint Molecules Macrophage CD Proteins
  5. TNF Superfamily Ligands OX40 Ligand/CD252
  6. OX40 Ligand
  7. OX40 Ligand/TNFSF4 蛋白, Rabbit (HEK293, hFc)

OX40 Ligand/TNFSF4 蛋白, Rabbit (HEK293, hFc)

目录号: HY-P700500
产品使用指南

OX40 配体/TNFSF4 蛋白是一种细胞因子，可与 TNFRSF4 结合，充当有效的 T 细胞共刺激剂，促进增殖和细胞因子的产生。作为同源三聚体，其与 TNFRSF4 的关键相互作用可通过激活和扩增 T 细胞来增强免疫反应。这种参与有助于复杂的调节，使 OX40 配体成为调节 T 细胞功能以实现有效和受控免疫激活的关键介质。OX40 Ligand/TNFSF4 蛋白, Rabbit (HEK293, hFc) 是重组的 OX40 配体/TNFSF4 蛋白，由 HEK293 表达，带有 C-hFc 标签。OX40 Ligand/TNFSF4 蛋白, Rabbit (HEK293, hFc) 全长 143 个氨基酸，分子量为 44.9 kDa。

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描述

OX40 Ligand/TNFSF4 Protein, a cytokine, binds TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production. As a homotrimer, its pivotal interaction with TNFRSF4 enhances immune response by activating and expanding T-cells. This engagement contributes to intricate regulation, making OX40 Ligand a key mediator in modulating T-cell functions for effective and controlled immune activation. OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc) is the recombinant Rabbit-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc) is 143 a.a., with molecular weight of 44.9 kDa.
研究背景

OX40 配体/TNFSF4 蛋白是一种细胞因子，与 TNFRSF4 特异性结合，发挥其作为 T 细胞增殖和细胞因子产生的有效共刺激剂的作用。作为同源三聚体，它与 TNFRSF4 的相互作用在通过促进 T 细胞的激活和扩增来增强免疫反应方面发挥着关键作用。通过这种参与，OX40 配体有助于 T 细胞介导的免疫反应的复杂调节，作为调节 T 细胞功能以实现有效和受控免疫激活的关键介质。
种属

Rabbit
表达系统

HEK293
标签

C-hFc
蛋白编号

O02765 (Q45-P187)
基因 ID

100008595  [NCBI]
蛋白结构
N-term
OX40L (Q45-P187)
Accession # O02765
hFc
C-term
同用名
Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; TNFSF4; CD252; TXGP1
氨基酸序列

QHSHAPEVSLQYPPIENIMTQLQILTSHECEEDSFILPLQKRDGTMEVQNNSVVIQCDGFYLLSLKGYFSQEVSISLHYRKGEEPFPILKKTKFANSNVVLKLGYKDKVYLNVTTDSASCKQLSVNAGELIVILQNPGGYCAP

分子量

44.9 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

OX40 Ligand/TNFSF4 Protein, Rabbit (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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