Plexin B2 蛋白, Human (HEK293, His)

Plexin B2 is a cell surface receptor for SEMA4C, SEMA4D, and SEMA4G and is involved in glutamatergic synapse development and SEMA4A-mediated excitatory synapse development. Plexin B2 activates downstream RHOA and ERBB2 phosphorylation, which is critical for promoting neuronal differentiation and migration. Plexin B2 Protein, Human (HEK293, His) is the recombinant human-derived Plexin B2 protein, expressed by HEK293 , with C-His labeled tag.

Plexin B2 (PLXNB2) 是 SEMA4C、SEMA4D 和 SEMA4G 的细胞表面受体，在细胞间信号传导中发挥着至关重要的作用。它参与谷氨酸能突触发育，并且是 SEMA4A 介导的兴奋性突触发育所必需的。与 4 类信号蛋白结合可诱导下游 RHOA 激活以及 ERBB2 在“Tyr-1248”处的磷酸化。PLXNB2对于大脑皮质发生过程中神经元细胞的正常分化和迁移至关重要，有助于胚胎大脑的正常发育，并调节发育中大脑中小脑颗粒细胞的迁移。此外，它在 RHOA 激活中发挥着关键作用，导致肌动蛋白细胞骨架的变化，并参与轴突引导、侵袭性生长和细胞迁移。PLXNB2 可以调节 RAC1 和 CDC42 的活性，它们以单体和与 PLXNB1 的异二聚体形式存在。此外，它还与 SEMA4C、SEMA4D、SEMA4G、MET、ARHGEF11、ARHGEF12 以及可能的 MST1R 相互作用。

Human

HEK293

C-His

O15031-1 (L20-R1160)

23654  [NCBI]

Partial

LRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKR

150-180 kDa

Greater than 90% as determined by reduced SDS-PAGE.

<1 EU/μg, determined by LAL method.