1. 重组蛋白
  2. Enzymes & Regulators
  3. Protease Inhibitors
  4. Serpin (Protease Inhibitor)
  5. Serpin B4
  6. Serpin B4 蛋白, Human (sf9, His)

Serpin B4 蛋白, Human (sf9, His)

目录号: HY-P77198
COA 产品使用指南 技术支持

Serpin B4 是一种蛋白酶抑制剂,可以调节宿主针对肿瘤细胞的免疫反应,这表明在微调免疫平衡中发挥着至关重要的作用。它抑制蛋白酶的能力强调了它在影响关键调节途径、增强免疫系统对抗癌细胞的有效性方面的重要性。Serpin B4 蛋白, Human (sf9, His) 是重组的 丝氨酸蛋白酶抑制剂 B4 蛋白,由 Sf9 insect cells 表达,带有 N-His 标签。

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50 μg ¥6500 In-stock
100 μg   询价  

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  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Serpin B4 is a protease inhibitor that may modulate the host immune response against tumor cells, suggesting a crucial role in fine-tuning immune balance. Its ability to inhibit proteases emphasizes its importance in influencing key regulatory pathways, enhancing the immune system's effectiveness against cancer cells. Serpin B4 Protein, Human (sf9, His) is the recombinant human-derived Serpin B4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

研究背景

Serpin B4 蛋白通过充当蛋白酶抑制剂,成为宿主针对肿瘤细胞的免疫反应的潜在调节剂。它作为调节剂的作用表明它在微调免疫反应的复杂平衡方面具有至关重要的功能,特别是在对抗肿瘤细胞的情况下。该蛋白质抑制蛋白酶的能力表明其影响关键调节途径的能力,可能增强免疫系统识别和应对癌细胞的有效性。Serpin B4 作为蛋白酶抑制剂,强调了其在免疫系统和肿瘤细胞之间动态相互作用中的重要性,使其成为进一步探索癌症免疫治疗的有希望的候选者。

生物活性

Measured by its ability to inhibit CMA1 cleavage of 100 µM fluorogenic peptide substrate Suc-AAPF-AMC (HY-137811) that incubate at room temperature in kinetic mode for 5 minutes. The IC50 is 15.514 nM.

种属

Human

表达系统

Sf9 insect cells

标签

N-His

蛋白编号

P48594 (M1-P390)

基因 ID
蛋白结构
N-term
His
Serpin B4 (M1-P390)
Accession # P48594
C-term
蛋白长度

Full Length

中文名
丝氨酸蛋白酶抑制 B4 蛋白
同用名
Serpin B4; Leupin; Peptidase inhibitor 11; PI-11; SCCA-2
分子量

Approximately 45 kDa

纯度

Greater than 88% as determined by reducing SDS-PAGE

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 20% Glycerol, 1 mM EDTA, 1 mM DTT. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

Serpin B4 Protein, Human (sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Serpin B4 Protein, Human (sf9, His)
目录号:
HY-P77198
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