2. 重组蛋白
  3. Enzymes & Regulators
  4. Protease Inhibitors
  5. Serpin (Protease Inhibitor)
  6. Serpin B8
  7. Serpin B8 蛋白, Mouse (sf9, His)

Serpin B8 蛋白, Mouse (sf9, His)

目录号: HY-P76641
产品使用指南

Serpin B8 蛋白在促进上皮桥粒介导的细胞间粘附方面发挥着关键作用，强调了其在维持上皮组织内细胞粘附方面的重要性。该蛋白质的参与表明对桥粒的结构完整性和稳定性有重要贡献，桥粒是介导相邻细胞之间粘附的关键细胞结构。Serpin B8 蛋白, Mouse (sf9, His) 是重组的 Serpin B8 蛋白，由 Sf9 insect cells 表达，带有 C-His 标签。Serpin B8 蛋白, Mouse (sf9, His) 全长 374 个氨基酸，分子量约为 ~43.6 kDa。

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3.  试用装只面向终端客户。

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描述

The Serpin B8 protein plays a critical role in promoting epithelial desmosome-mediated intercellular adhesion, underscoring its importance in maintaining cell adhesion within epithelial tissues. The protein's involvement suggests an important contribution to the structural integrity and stability of desmosomes, key cellular structures that mediate adhesion between adjacent cells. Serpin B8 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B8 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B8 Protein, Mouse (sf9, His) is 374 a.a., with molecular weight of ~43.6 kDa.
研究背景

Serpin B8 在上皮桥粒介导的细胞间粘附中起着至关重要的作用。该蛋白质在这方面的重要性强调了它通过调节桥粒相互作用来维持上皮组织的结构完整性和稳定性。作为丝氨酸蛋白酶抑制剂家族的一员，丝氨酸蛋白酶抑制剂 B8 可能通过调节蛋白酶活性来发挥其影响，从而有助于适当细胞粘附所需的复杂平衡。进一步探索桥粒介导的粘附中涉及 Serpin B8 的具体机制和相互作用，可能会深入了解其对组织稳态的更广泛影响，并可能揭示其与上皮完整性相关病理状况的相关性。
种属

Mouse
表达系统

Sf9 insect cells
标签

C-His
蛋白编号

O08800 (M1-P374)
基因 ID

20725  [NCBI]
蛋白结构
N-term
Serpin B8 (M1-P374)
Accession # O08800
His
C-term
同用名
Cytoplasmic antiproteinase 2; CAP-2; Peptidase inhibitor 8; PI-8; SERPINB8
分子量

Approximately 43.6 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Serpin B8 Protein, Mouse (sf9, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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