TMEFF2/Tomoregulin-2 蛋白, Human (HEK293, His)

TMEFF2/Tomoregulin-2 protein serves as a potential survival factor for hippocampal and midbrain neurons, supporting neuronal cell viability. In addition, its shed form may upregulate cancer cell proliferation by promoting ERK1/2 phosphorylation. TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is the recombinant human-derived TMEFF2/Tomoregulin-2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is 280 a.a., with molecular weight of 32.3 kDa.

TMEFF2/Tomoregulin-2 蛋白作为海马和中脑神经元的潜在生存因子出现，表明其在支持神经细胞活力中的作用。除了其神经保护功能外，脱落形式的 TMEFF2/Tomoregulin-2 还可能通过促进 ERK1/2 磷酸化来上调癌细胞增殖。这种双重作用表明 TMEFF2 在神经元存活和癌细胞增殖中发挥着复杂的作用，凸显了 TMEFF2 在不同细胞环境中的多功能性。进一步探索 TMEFF2 对神经元和癌细胞功能影响的机制可以为其在神经和癌症生物学中的具体作用和潜在治疗意义提供有价值的见解。

Measured by its binding ability in a functional ELISA. Immobilized Human TMEFF2 at 2 μg/mL can bind Anti-TMEFF2 recombinant antibody, the EC₅₀ is ≤7 ng/mL.

Human

HEK293

C-10*His

Q9UIK5 (F41-V320)

23671  [NCBI]

FPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYV

47 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.