2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (rel)-Asperparaline A

(rel)-Asperparaline A  (Synonyms: (rel)-Aspergillimide; (rel)-VM55598)

目录号: HY-124874
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摩尔计算器

(rel)-Asperparaline A ((rel)-Aspergillimide)，是一种从 Aspergillus japonicas JV-23 发酵的豆渣中分离得到的驱虫代谢产物。(rel)-Asperparaline A 也是一种有效和选择性的 nAChR 拮抗剂。(rel)-Asperparaline A 在蚕中表现出麻痹作用。

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(rel)-Asperparaline A Chemical Structure

(rel)-Asperparaline A Chemical Structure

CAS No. : 195966-93-9

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规格 价格 是否有货 数量
5 mg ￥8748
3 - 4 周
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(rel)-Asperparaline A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms[1][2].

体外研究
(In Vitro)

Asperparaline A (1 μM; 1 min) markedly and reversibly blocks the acetylcholine (Ach; 10 µM)-induced current in the silkworm larval neurons[2].
Asperparaline A (1-1000 nM; 1 min) differentially blocks the peak and slowly desensitizing currents, with IC50s of 20.2 and 39.6 nM, respectively[2].
Asperparaline A (10 μM; 1 min) reduces the peak current amplitude of the ACh (100 µM)-induced response of α3β4 nAChR by 33.4%, while barely influencing the amplitudes of the responses to ACh of the α4β2 and α7 nAChRs in X. laevis oocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(rel)-Asperparaline A 相关抗体:
体内研究
(In Vivo)

Asperparaline A (10 μg/g; p.o.) exhibits paralysis against silk worms within 1 h and lasts for 7 to 10 h[1].
Asperparaline A (3 μg/g; injection with a micro-syringe) exhibits paralysis activity against silk worms within 20 min and lasts for 4 to 5 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

359.46

Formula

C20H29N3O3
CAS 号
结构分类
初始来源

Aspergillus japonicus JV-23
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(rel)-Asperparaline A 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(rel)-Asperparaline A195966-93-9(rel)-Aspergillimide (rel)-VM55598nAChRNicotinic acetylcholine receptorsanthelminticokaraAspergillusjaponicasparalyticInhibitorinhibitorinhibit

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