2. Others Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. HDAC Isotope-Labeled Compounds Apoptosis
  4. Romidepsin-d7

Romidepsin-d7  (Synonyms: FK 228-d7; FR 901228-d7; NSC 630176-d7)

目录号: HY-15149S2
产品使用指南 技术支持

Romidepsin-d7 (FK 228-d7) 是氘代标记的 Romidepsin. Romidepsin (FK 228) 是具有抗肿瘤活性的组蛋白去乙酰化酶 (HDAC) 抑制剂，抑制 HDAC1，HDAC2，HDAC4 和 HDAC6，IC50 值分别为 36 nM，47 nM，510 nM 和 1.4 μM。Romidepsin (FK 228) 由紫色杆菌产生，诱导 G2/M 细胞周期阻滞和凋亡 (apoptosis)。

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Romidepsin-d<sub>7</sub> Chemical Structure

Romidepsin-d7 Chemical Structure

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Other Forms of Romidepsin-d7:

Romidepsin-d7 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Romidepsin-d7 (FK 228-d7) is deuterium labeled Romidepsin. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Romidepsin-d7 相关抗体:
分子量

547.74

同用名

FK 228-d7; FR 901228-d7; NSC 630176-d7

Formula

C24H29D7N4O6S2
非标记 CAS
中文名称

罗米地辛-d7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Romidepsin-d7 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romidepsin-d7FK 228-d7 FR 901228-d7 NSC 630176-d7罗米地辛-d7HDACIsotope-Labeled CompoundsApoptosisHistone deacetylasesInhibitorinhibitorinhibit

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