2. NF-κB
  3. NF-κB
  4. RS47

RS47 (Compound 1a) 是一种非经典 NF-κB 信号通路的选择性抑制剂，靶向 RelB，Kd 值为 1.1 μM。RS47 能够竞争性地阻止 RelB 与靶向 DNA 的结合，从而抑制下游基因 (如 BCL3、PIM2) 的表达，进而抑制肿瘤细胞的增殖。RS47 有望用于非经典 NF-κB 通路异常激活的癌症的研究，如结肠癌和 B 淋巴瘤。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

RS47 Chemical Structure

RS47 Chemical Structure

CAS No. : 301655-16-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

RS47 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS47 (Compound 1a) is a selective inhibitor of the non-canonical NF-κB signaling pathway targeting RelB with a Kd of 1.1 μM. RS47 competitively blocks RelB binding to target DNA, inhibiting downstream gene (e.g., BCL3, PIM2) expression, thereby suppressing tumor cell proliferation. RS47 is promising for research of cancers with aberrant activation of the non-canonical NF-κB pathway, such as colorectal cancer and B lymphoma[1][2].

分子量

354.43

Formula

C18H18N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS47 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS47301655-16-3RS 47RS-47NF-κBNuclear factor-κBNuclear factor-kappaBRelBBCL3PIM2colorectal cancerB lymphomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
RS47
目录号：
HY-171579
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z