2. Apoptosis
  3. TNF Receptor
  4. Ruplizumab

Ruplizumab  (Synonyms: 卢利珠单抗; BG 9588; Anti-Human CD40L Recombinant Antibody; Hu5c8)

目录号: HY-P99315 纯度: 99.84%
COA 技术支持

Ruplizumab (BG 9588) 是一种人源化抗 CD40L IgG1κ 单克隆抗体。Ruplizumab 通过与 CD40L 结合阻断其与 CD40 受体的相互作用，抑制 T-B 细胞共刺激信号并通过 Fc 段介导活化 T 细胞耗竭，从而发挥免疫抑制作用。Ruplizumab 可用于系统性红斑狼疮、器官移植排斥反应和自身免疫性疾病的研究。推荐同型对照为人 IgG1 kappa，同型对照 (HY-P99001)。

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CAS No. : 220651-94-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2500
In-stock
5 mg ￥6500
In-stock
10 mg   询价  
50 mg   询价  

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Ruplizumab 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to CD40L, Ruplizumab blocks its interaction with the CD40 receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2].

IC50 & Target

TNFSF5/CD40L/CD154
体内研究
(In Vivo)

Ruplizumab 在恒河猴肾移植模型中延长了移植物存活时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
基因 ID

959  [NCBI]

Accession
分子量

145.68 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

卢利珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: 99.84%

COA (265 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Ruplizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruplizumab220651-94-5BG 9588 Anti-Human CD40L Recombinant Antibody Hu5c8卢利珠单抗BG9588BG-9588TNF ReceptorTumor Necrosis Factor ReceptorTNFRsystemic lupus erythematosushumanized IgG1κ monoclonal antibodyorgan transplant rejectionautoimmune diseasesInhibitorinhibitorinhibit

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